Volume : 13, Issue : 08, August – 2026

Title:

DESIGN AND DEVELOPMENT OF LOVASTATIN MOUTH DISSOLVING TABLETS BY USING NOVEL SUPER DISINTEGRANTS

Authors :

Md. Nabila*, Mr. CH. Rajveer

Abstract :

Mouth dissolving tablets are a vital tool in keeping our children and elderly population healthy. Their ease of use and accurate dosing allow higher patient compliance and more reliable therapeutic effects. Superdisintegrants are the fundamental element contained in Mouth dissolving tablets and are responsible for their unique ability to quickly disintegrate and dissolve on the surface of the tongue without the use of any additional liquid. In order to determine the most effective type and optimal amount of superdisintegrants for orally disintegrating tablets manufactured by direct compression, the following tablet parameters were tested hardness, thickness, friability, disintegration time, and wetting time. Three superdisintegrants were tested, namely: Kyron T-314, Ac-Di-Sol, and Banana Powder and the most efficient superdisintegrant was selected based on the above mentioned studies. From the results obtained, it can be concluded that the tablet formulation (F3) showed the promising formulation also the hardness, friability, disintegration time and dissolution rate of prepared tablets were found to be acceptable according to standard limits.
Keywords: Lovastatin, Kyron T-314, Ac-Di-Sol, Banana Powder and Mouth dissolving tablets.

Cite This Article:

Please cite this article in press Md. Nabila et al., Design and development of Lovastatin mouth dissolving tablets by using novel super disintegrants. Indo Am. J. P. Sci, 2026; 13(08).

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Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

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