Volume : 13, Issue : 08, August – 2026
Title:
MORINGA OLEIFERA: AN INTEGRATED REVIEW OF PHYTOCHEMISTRY, MOLECULAR MECHANISMS, CLINICAL TRANSLATION, AND NANO-DELIVERY SYSTEMS
Authors :
Soma Sekhar Pulamarasetti*, Omkar Rai, Deepshikha Dey, L. N. Patidar, Deepak Jain
Abstract :
Moringa oleifera Lam. The “Miracle Tree” (Moraceae), a rich source of bioactive phytochemicals, has significant medicinal properties [1, 2]. The plant is utilized in traditional medicine for its various sections and modern ethnopharmacology has been trying to elucidate the exact molecular targets, therapeutic benefits and the translation potential of the plant [3].This review brings together up to date information regarding M. oleifera, its major phytoconstituents such as glucosinolates, isothiocyanate (moringin), flavonoids (quercetin, kaempferol), chlorogenic acid and alkaloids [11, 12, 18]. We map out its primary molecular signaling pathways, highlighting how it regulates the Nrf2/ARE antioxidant defense, suppresses NF-κB/MAPK inflammatory cascades, activates AMPK/GLUT4 metabolic pathways, and modulates Bcl-2/Bax/Caspase-3 apoptotic signaling [22, 23, 27]. We also discuss human clinical studies in the metabolic, immunomodulatory and antioxidant fields, where major translational gaps exist [4, 5, 31]. Finally, recent breakthroughs in biogenic green nanotechnology and smart nano-delivery systems to address native solubility and bioavailability restrictions are highlighted [44, 46]. This review integrates a framework to fill the space between benchtop phytochemistry and clinical applications [8, 9, 10].
Keywords: Moringa oleifera, Moringin, Phytoconstituents, Nrf2 Pathway, NF-κB Pathway, AMPK, Nano-formulations, Clinical Trials, Pharmacokinetic.
Cite This Article:
Please cite this article in press Soma Sekhar P et al., Moringa Oleifera: An Integrated review of Phytochemistry, molecular mechanisms, clinical translation, and nano-delivery systems. Indo Am. J. P. Sci, 2026; 13(08).
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Volume : 13, Issue : 08, August – 2026
Title:
EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS
Authors :
Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan
Abstract :
Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.
Cite This Article:
Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).
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