Volume : 13, Issue : 08, August – 2026

Title:

BEYOND ANTIMICROBIAL THERAPY : A CASE SERIES OF LINEZOLID ASSOCIATED ADVERSE DRUG REACTIONS IN A TERTIARY TEACHING HOSPITAL

Authors :

* Rini Sara John, Dr. Parvathy P.R,Dr.Harikrishnan S ,Dr. Akhil Joseph Issac

Abstract :

Linezolid is the first clinically approved oxazolidinone antibiotic, which is vitally used to treat multi drug-resistant gram-positive infections due to its excellent oral bioavailability, effective tissue distribution and favourable pharmacokinetics. Extended or inappropriate use has increasingly been linked to significant adverse drug reactions such as hematological related toxicity, metabolic, neurological and immune system complications. This retrospective case series describes ten patients who developed linezolid-associated adverse drug reactions during treatment. Cases were identified through adverse drug reaction monitoring centre and evaluated using medical records, medication history, laboratory findings, temporal association, management and other follow up outcomes. The adverse reactions included hypoglycaemia, anemia, leukopenia, thrombocytopenia, DRESS syndrome, peripheral neuropathy, hypotension and neuropsychiatric toxicity. Most reactions occurs in patients with potential risk factors such as advanced age, diabetes mellitus, renal dysfunction, malignancy or prolonged therapy. Causality assessment using the WHO-UMC and Naranjo scale classified most reactions as probable. Linezolid was discontinued in all cases, with supportive and specific management provided. All patients showed clinical improvement after discontinuation .These findings emphasize the need for early recognition, regular laboratory monitoring, and individualized risk assessment during linezolid therapy, particularly in vulnerable patients receiving prolonged treatment or significant comorbidities.
Keywords: Linezolid, adverse drug reactions, myelosuppression, hypoglycemia, thrombocytopenia, leukopenia, peripheral neuropathy, DRESS syndrome, pharmacovigilance

Cite This Article:

Please cite this article in press Rini Sara John et al., Beyond Antimicrobial Therapy : A Case Series Of Linezolid Associated Adverse Drug Reactions In A Tertiary Teaching Hospital. Indo Am. J. P. Sci, 2026; 13(08).

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Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

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