Volume : 13, Issue : 08, August – 2026

Title:

GREEN CHEMISTRY IN PHARMACEUTICAL DRUG DISCOVERY: SUSTAINABLE SYNTHETIC STRATEGIES, CATALYSIS, AND FUTURE PERSPECTIVES

Authors :

Omkar Rai*, Soma Sekhar Pulamarasetti, Manish Gupta, Kovvada Vandana, Vishva Prakash

Abstract :

In pharmaceutical discovery, potency, selectivity, pharmacokinetics, safety and manufacturability have traditionally been optimized, with environmental performance often considered later in process development. But this separation is becoming increasingly untenable, as discovery routes can consume large quantities of solvents and reagents, produce large amounts of waste, and depend on rare or hazardous materials. Green chemistry is a proactive strategy designed to reduce waste, hazards, energy requirements, and resource consumption at the molecular and reaction-design levels rather than after pollution has been generated. This review formulates an integrated view on sustainable pharmaceutical drug discovery with a focus on catalysis, biocatalysis, safer solvents, solvent minimization, one-pot and multicomponent synthesis, continuous-flow processing, photochemistry, electrochemistry, mechanochemistry, microwave-assisted synthesis, renewable feedstocks, green purification and life-cycle assessment. It also proposes a Sustainable Synthesis-to-Process (S2P) framework linking molecular design to retrosynthetic planning, reaction optimization, process intensification, quantitative green metrics, and scale-up. Special emphasis is placed on process mass intensity (PMI), E-factor, atom economy, reaction mass efficiency, energy intensity, carbon footprint and life-cycle assessment. Recent literature also supports the use of artificial intelligence and automated experimentation to multi-objectively optimize yield and sustainability. The review argues that the most important transition is conceptual: green chemistry should be factored in as a design variable in drug discovery, rather than as a downstream manufacturing correction .
Keywords: green chemistry; pharmaceutical synthesis; drug discovery; sustainable catalysis; biocatalysis; green solvents; flow chemistry; process intensification; mechanochemistry; photocatalysis; electrochemistry; PMI; life-cycle assessment; artificial intelligence.

Cite This Article:

Please cite this article in press Omkar Rai et al., Green Chemistry In Pharmaceutical Drug Discovery: Sustainable Synthetic Strategies, Catalysis, And Future Perspectives. Indo Am. J. P. Sci, 2026; 13(08).

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Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

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