Volume : 13, Issue : 08, August – 2026
Title:
BENZOTHIAZOLE A PRIVILEGED HETEROCYCLIC SCAFFOLD IN MEDICINAL CHEMISTRY
Authors :
Likhit kumar J Punjali, Anusha P. Shalavadi, Tabasum Killedar*, Sadhya D C, V H. Kulkarni, S D. Joshi
Abstract :
Benzothiazole is a privileged sulphur and nitrogen containing heterocyclic scaffold that has attracted considerable attention in medicinal chemistry owing to its structural diversity, ease of functionalization, and broad spectrum of biological activities. The unique physicochemical properties of the benzothiazole nucleus enable the development of structurally diverse derivatives with significant therapeutic potential. This review provides a comprehensive overview of the chemistry of benzothiazole, including its structural features, aromatic characteristics, and commonly employed synthetic strategies for the preparation of biologically active derivatives. Particular emphasis is placed on the recent advances in the pharmacological applications of benzothiazole derivatives, highlighting their antitubercular, anticancer, antifungal, anti-inflammatory, antidiabetic, anticonvulsant, antioxidant, antimalarial, and antidepressant activities, together with representative lead compounds and their biological significance. In addition, clinically approved drugs containing the benzothiazole scaffold are discussed to demonstrate the successful translation of this pharmacophore into therapeutic agents. Overall, this review highlights the versatility of the benzothiazole nucleus as a valuable platform for rational drug design and underscores its continuing importance in the discovery and development of next-generation pharmaceuticals.
Keywords: Benzothiazole, Medicinal Chemistry, Heterocyclic Scaffold, Pharmacological Activities, Drug Discovery.
Cite This Article:
Please cite this article in press Tabasum Killedar et al., Benzothiazole A Privileged Heterocyclic Scaffold In Medicinal Chemistry. Indo Am. J. P. Sci, 2026; 13(08).
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Volume : 13, Issue : 08, August – 2026
Title:
EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS
Authors :
Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan
Abstract :
Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.
Cite This Article:
Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).
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