Volume : 13, Issue : 09, September – 2026
Title:
EVALUATION OF IN-VIVO ANTIUROLITHIATIC ACTIVITY OF METHANOLIC LEAF EXTRACTS OF ACALYPHA INDICA LINN
Authors :
Radhika Patel*, Akriti Kushawaha
Abstract :
The present study is designing to evaluate the invivo anti-urolithiatic activity of methanolic leaf extracts of Acalypha indica.L. Urolithiasis is a common and a major cause of morbidity worldwide. After administering 0.75% ethylene glycol (EG) in the drinking water, all mice consistently developed crystalluria, marked by the presence of both calcium oxalate monohydrate (COM) and dihydrate (COD) crystals. COM crystals typically appeared as distinctive biconcave ovals, whereas COD crystals displayed dipyramidal shapes. Notably, untreated nephrolithiatic mice exhibited a greater abundance of large COM crystals in their urine. Urinary microscopy confirmed that EG treatment significantly increased both the number and size of calcium oxalate crystals. Treatment were given from 1 st – 21th day administer 0.75% EG in Drinking Water with Standard drug (Cystone 40 mg/kg) and test extract at doses 20 mg/kg and 40 mg/kg respectively. Results of all biochemical test were statistically significant as compare to disease control group. In contrast, mice treated with test extract showed a clear reduction in both the number and size of calcium oxalate crystals. Nevertheless, when compared head-to-head with a group receiving Cystone at 40 mg/kg, the Cystone-treated mice demonstrated a more pronounced decrease in crystalluria.
Keywords:Urolithiasis, Acalypha indica, Calcium oxalate, Ethylene glycol, and Cystone.
Cite This Article:
Please cite this article in press Radhika Patel et al., Evaluation Of In-Vivo Antiurolithiatic Activity Of Methanolic Leaf Extracts Of Acalypha Indica Linn.,. Indo Am. J. P. Sci, 2026; 13(09).,
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