Volume : 13, Issue : 09, September – 2026
Title:
EVALUATION OF ANTIULCER ACTIVITY OF PLUMERIA PUDICA FLOWERS ON WISTAR ALBINO RATS
Authors :
Hithesh C M*, Ahalyadevi K H, Suresha B S, T. Balasubramanian
Abstract :
The present study evaluated the antioxidant, acid-neutralizing, and gastroprotective activities of the hydroethanolic flower extract of Plumeria pudica. The extract exhibited concentration-dependent DPPH radical scavenging activity, increasing from 18.83% at 20 µg/mL to 66.92% at 100 µg/mL, with an IC₅₀ value of 70.36 µg/mL. HEPP also demonstrated antioxidant activity in the phosphomolybdate and ferric reducing assays, with ascorbic-acid-equivalent activities of 10.44 and 14.35 µg/mL, respectively. The extract showed acid-neutralizing capacity ranging from 261.51 to 27.15 mEq/g at the tested concentrations. In the ethanol-induced gastric ulcer model, HEPP at 250 and 500 mg/kg reduced the ulcer index to 2.08 ± 0.20 and 1.75 ± 0.11, respectively, compared with 2.67 ± 0.21 in the ulcer-control group. Overall, the findings demonstrate that the hydroethanolic flower extract of P. pudica possesses antioxidant, acid-neutralizing, and gastroprotective properties.
Keywords: Plumeria pudica, hydroethanolic extract, anti-ulcer activity, gastric ulcer, antioxidant activity, DPPH, acid-neutralizing capacity, Wistar albino rats.
Cite This Article:
Please cite this article in press Hitesh CM et al., Evaluation Of Antiulcer Activity Of Plumeria Pudica Flowers On Wistar Albino Rats.,. Indo Am. J. P. Sci, 2026; 13(09).
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