Volume : 13, Issue : 09, September – 2026
Title:
DEVELOPMENT AND CHARACTERIZATION OF GANCICLOVIR-LOADED ETHOSOMAL GEL WITH IN VITRO EVALUATION
Authors :
Dr. Y. Ganesh Kumar, P. Sreeya Laxmi, P. Lavanya, P. Sai Nandhini, P. Sumanth, P. Pranika
Abstract :
The present study was aimed at formulating and evaluating Ganciclovir-loaded ethosomes to enhance drug delivery and improve therapeutic performance through a vesicular carrier system.Ganciclovir-loaded ethosomes were prepared using phosphatidylcholine and ethanol by the cold method. Eight formulations (F1–F8) were developed with varying concentrations of phosphatidylcholine and ethanol and evaluated for physicochemical characteristics, drug-excipient compatibility, vesicle size, zeta potential, entrapment efficiency, in vitro drug release and stability. Preformulations studies including organoleptic evaluation, melting point determination, solubility studies, UV spectroscopic analysis and FTIR studies were carried out. The λmax of Ganciclovir was found to be 252 nm, and the calibration curve showed good linearity in the concentration range of 10–50 µg/mL with a correlation coefficient (R²) of 0.997. FTIR studies confirmed the compatibility of Ganciclovir with the selected excipients.The particle size of the ethosomal formulations ranged from 163 to 238 nm, while zeta potential values ranged from –21 to –32 mV, indicating good stability of the vesicles. SEM analysis confirmed the spherical morphology and uniform distribution of ethosomes. Drug entrapment efficiency ranged from 70.80% to 85.50%, with formulation F4 exhibiting the highest entrapment efficiency. In vitro drug release studies demonstrated sustained drug release over 8 hours, with formulation F4 showing a cumulative drug release of 97.48%. Stability studies conducted under accelerated conditions for three months indicated no significant changes in the formulation characteristics, confirming good stability.Based on particle size, zeta potential, entrapment efficiency, drug release profile and stability studies, formulation F4 was identified as the optimized formulation. The study concluded that ethosomal delivery of Ganciclovir is a promising approach for improving drug delivery, enhancing stability and achieving sustained release.
Keywords: Ganciclovir, Ethosomes, FTIR Studies, In vitro drug release studies, Stability studies
Cite This Article:
Please cite this article in press Y Ganesh Kumar et al., Development And Characterization Of Ganciclovir-Loaded Ethosomal Gel With In Vitro Evaluation.,. Indo Am. J. P. Sci, 2026; 13(10).
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