26.Issue 10 october 26 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 13, Issue : 10, October – 2026

Title:

FORMULATION DEVELOPMENT AND IN VITRO CHARACTERISATION OF ENTECAVIR MICROSPHERES

Authors :

Masireddy Tejasri*, Shaik Zareena Begum

Abstract :

Oral route drug administration is by far the most preferable route for taking medications. However, their short circulating half life and restricted absorption via a defined segment of intestine limits the therapeutic potential of many drugs. Such a pharmacokinetic limitation leads in many cases to frequent dosing of medication to achieve therapeutic effect. Rational approach to enhance bioavailability and improve pharmacokinetic and pharmacodynamics profile is to release the drug in a controlled manner and site specific manner. Microspheres are small spherical particles, with diameters 1 μm to 1000 μm. They are spherical free flowing particles consisting of proteins or synthetic polymers which are biodegradable in nature. There are two types of microspheres; microcapsules and micromatrices, which are described as, Microcapsules are those in which entrapped substance is distinctly surrounded by distinct capsule wall. and micromatrices in which entrapped substance is dispersed throughout the matrix. Microspheres are sometimes referred to as microparticles. Microspheres can be manufactured from various natural and synthetic materials. Microsphere play an important role to improve bioavailability of conventional drugs and minimizing side effects.

Cite This Article:

Please cite this article in press Masireddy Tejasri et al., Formulation Development And In Vitro Characterisation Of Entecavir Microspheres.,. Indo Am. J. P. Sci, 2026; 13(10).

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