Volume : 13, Issue : 10, October – 2026
Title:
PREPATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF FOSINOPRIL BY DIRECT COMPRESSION METHOD
Authors :
Mourya Rajender*, Ch. Sunitha
Abstract :
The present research was aimed at the preparation and evaluation of mouth dissolving tablets of Fosinopril by the direct compression method to enhance patient compliance and ensure rapid onset of action. Various formulations were developed using different concentrations of suitable super disintegrants and directly compressible excipients. The pre-compression parameters such as angle of repose, bulk density, tapped density, and compressibility index were evaluated and found to be within the acceptable limits of I.P., indicating good flow properties of the powder blend. The prepared tablets were further assessed for post-compression parameters including hardness, friability, weight variation, thickness, drug content uniformity, disintegration time, wetting time, and in vitro drug release. All formulations complied with I.P. specifications, demonstrating good mechanical strength and acceptable physicochemical properties. Among the developed batches, Formulation F6 was identified as the optimized formulation, as it exhibited rapid disintegration, acceptable friability, uniform drug content, and maximum drug release in a short time.
The study concludes that mouth dissolving tablets of Fosinopril prepared by direct compression provide a promising dosage form with improved patient convenience, especially for paediatric, geriatric, and dysphagic patients, while ensuring effective therapeutic performance.
Keywords: Fosinopril , Mouth Dissolving Tablets
Cite This Article:
Please cite this article in press Mourya Rajender et al., Prepation And Evaluation Of Mouth Dissolving Tablets Of Fosinopril By Direct Compression Method.,. Indo Am. J. P. Sci, 2026; 13(10).
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