Volume : 08, Issue : 01, January – 2021

6. THE COMPARISON OF THE LEVEL OF CREATININE AND CYSTATIN C FOR THE INDICATION OF EARLY-STAGE DIABETIC NEPHROPATHY TO SCREEN OUT DIABETIC PATIENTS

Dr. Muhammad Ahmad Raza, Dr. Maria Aslam, Dr. Abdullah Muhammad Ashfaq

Abstract :

Objective: The aim of our study was to compare the level of creatinine and cystatin C for the indication of early-stage diabetic nephropathy to screen out diabetic patients.
Study Design: A cross-sectional study.
Place and Duration: This study was conducted at Services hospital Lahore for the duration of one year starting from October, 2019 to September, 2020.
Methodology: In our study we selected 154 subjects from which 77 healthy subjects were in control group and 77 patients of diabetes were in patient group, and their age range was more than 18 years. We use IMAGIN Specific Protein Analyzer to measure the level of creatinine and serum cystatin C. Standardized laboratory protocols were applied to carry out both tests. SPSS version 20 for the analysis of data. The results of study were determined in terms of detection of diabetic nephropathy which were finalized on albuminuria status basis and categorized in three groups: microalbuminuria, normoalbuminuria and macroalbuminuria.
Results: In our present study we selected 154 subjects. According to gender distribution the number females were 41.6% and the number of males were 58.4%, and they were equally distributed in control and patient group. As compared to control and normoalbuminuria groups the level of creatinine (1.0 ± 0.13 mg/dl) and level of Cystatin C (4.7 ± 3.9 mg/dl) were significantly found high in macroalbuminuric group.
Conclusion: At the end of our study, we conclude that serum cystatin C is a significant predictive marker of diabetic nephropathy than serum creatinine.

Keywords :Serum Creatinine, Diabetic Nephropathy, Serum Cystatin C

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