Volume : 13, Issue : 11, November – 2026
Title:
PHARMACOLOGICAL EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF BY USING IPOMEA HEDERIFOLIA IN VIVO STUDIES
Authors :
M Meena Kumari*, Syed Sumair
Abstract :
Inflammation is a complex biological response to tissue injury, infection, or irritation and is associated with the release of various inflammatory mediators and oxidative stress. The present study was designed to evaluate the anti-inflammatory activity of the ethanolic extract of Ipomoea hederifolia using in vivo experimental models. The anti-inflammatory activity was assessed using carrageenan-induced paw edema for acute inflammation and cotton pellet-induced chronic inflammation in Wistar albino rats. Animals were divided into five groups: normal control, negative control, standard diclofenac-treated group (10 mg/kg), and two extract-treated groups receiving Ipomoea hederifolia extract at doses of 200 mg/kg and 500 mg/kg, respectively. In the carrageenan-induced paw edema model, the extract produced a significant and dose-dependent reduction in paw swelling compared with the negative control group. In the chronic inflammation model, the extract significantly reduced inflammatory tissue formation, indicating inhibition of the proliferative phase of inflammation. Biochemical analysis demonstrated a significant decrease in pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and C-reactive protein (CRP), in extract-treated animals. Furthermore, the extract restored antioxidant enzyme levels such as superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH), while significantly reducing malondialdehyde (MDA) levels. The higher dose (500 mg/kg) exhibited greater anti-inflammatory and antioxidant effects, comparable to those of diclofenac sodium. The findings suggest that the ethanolic extract of Ipomoea hederifolia possesses significant anti-inflammatory activity, possibly mediated through the suppression of inflammatory mediators and enhancement of antioxidant defense mechanisms. Therefore, Ipomoea hederifolia may represent a promising natural source for the development of anti-inflammatory therapeutic agents.
Keywords: Ipomoea hederifolia, Anti-inflammatory activity, Carrageenan-induced paw edema, Chronic inflammation, Diclofenac sodium, Pro-inflammatory cytokines.
Cite This Article:
Please cite this article in press M Meena Kumari et al., Pharmacological Evaluation Of Anti-Inflammatory Activity Of Ethanolic Extract Of By Using Ipomea Hederifolia In Vivo Studies.,. Indo Am. J. P. Sci, 2026; 13(11).
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