Volume : 13, Issue : 11, November – 2026

Title:

DEVLOMENT OF MUCOADHESIVE BUCCAL FILM OF ZOLMITRIPTAN FOR RAPID MIGRAINE

Authors :

Shivani Chandra Jadhav, Shaistha Khanam, Marikatti Parimala, Kore Prabhakar, Nagula Jashwanth

Abstract :

The present study focuses on the development and evaluation of a Zolmitriptan buccal film to enhance bioavailability, ensure sustained therapeutic effect, and improve patient compliance. Buccal films were prepared using mucoadhesive polymers via the solvent casting method, incorporating suitable plasticizers to achieve flexibility and uniformity. Formulations were evaluated for physical characteristics, including thickness, weight uniformity, and drug content, all of which met pharmacopeial standards. In vitro drug release studies demonstrated sustained release over 8 hours, with the optimized formulation (F4) achieving approximately 97.85% cumulative release. Stability studies under various temperature and humidity conditions (25°C/60% RH, 30°C/75% RH, 40°C/75% RH) revealed no significant changes in physical properties or drug release over 90 days, highlighting the formulation’s robustness. Overall, the developed Zolmitriptan buccal film demonstrates a safe, stable, and patient-friendly platform for sustained drug delivery, offering potential advantages over conventional oral dosage forms in pain management and opioid therapy.
Keywords: Zolmitriptan, FTIR Studies, Solvent evaporation method, Polymers, In vitro drug release studies

Cite This Article:

Please cite this article in press Shivani Chandra Jadhav et al., Devloment Of Mucoadhesive Buccal Film Of Zolmitriptan For Rapid Migraine.,. Indo Am. J. P. Sci, 2026; 13(11).

REFERENCES:

1. Shidhaye, Mucoadhesive Bilayered Patches for Administration of Sumatriptan, AAPS Phramscitech, 9 (2009) 1-13.
2. A Puratchikody, V Prasanth, ST Mathew, KB Ashok, Buccal Drug Delivery: Past, Present and Future A Review. Inter National Journal of Drug Delivery, 3(2011) 71-84.
3. A Ahuja, RK Khan, J Ali, Mucoadhesive Drug Delivery System, Drug Develop Indus Phram 23(1997)489-515.
4. Sang-Chul Shin, Jin-Pil Bum, Jun-Shik Choi. Enhanced bioavailability by buccal administration of triamcinolone acetonide from the bioadhesive gels in rabbits, Int. J. Pharmaceutics., 2009; 209:37-43.
5. FC Carvalho ,ML Bruschi ,RC Evangelista , Mucoadhesive Drug Delivery System, Brazilian Journal Of Pharmaceutical Sciences,4( 2010) 1-17.
6. Yadav GV, Singh SR. Nanosuspension: A promising drug delivery system. Pharmacophore. 2012; 3(5):217-43.
7. Geetha G, Poojitha U, Khan KA. Various techniques for preparation of nanosuspension-A Review. International Journal of Pharma Research & Review. 2014 Sep; 3(9):30-7.
8. Pawar SS, Dahifale BR, Nagargoje SP, Shendge RS. Nanosuspension technologies for delivery of drugs. J Nanosci Nanotechnol. 2017; 4(2):59-66.
9. Kilor V, Sapkal N, Daud A, Humne S, Gupta T. Development of stable nanosuspension loaded oral films of glimepiride with improved bioavailability. Int J Appl Pharm. 2017 Mar 1; 9(2):28-33.
10. Bhadoriya SS, Mangal A, Madoriya N, Dixit P. Bioavailability and bioactivity enhancement of herbal drugs by “Nanotechnology”: a review. J Curr Pharm Res. 2011; 8:1-7.
11. Bonifacio BV, da Silva PB, dos Santos Ramos MA, Negri KM, Bauab TM, Chorilli M. Nanotechnology-based drug delivery systems and herbal medicines: a review. International journal of nanomedicine. 2014; 9:1.
12. Mishra, R., Amin, A. 2011. Formulation and characterization of rapidly dissolving films of cetirizine hydrochloride using pullulan as a film forming agent. Ind. J. Pharm. Edu. Res. 45(1), 71-77.
13. Cilurzo, F., 2010. Nicotine fast dissolving films made of maltodextrins: A feasibility study. AAPS Pharm. Sci. Tech. 11(4), 1511-1517.
14. Kunte, S., Tandale, P., 2010. Fast dissolving strips: A novel approach for the delivery of verapamil. J. Bioallied Sci. 2, 325-328.
15. Sudeendra, B.R., Umme, H., Gupta, R.K., Shivakumar, H.G., 2010. Development and characterization of bioadhesive vaginal films of clotrimazole for vaginal candidiasis. Acta Pharmaceutica Sciencia. 52, 417-426.
16. Dixit, R.P., Puthli, S.P., 2009. Oral strip technology: Overview and future potential. J. Control. Release. 139(2), 94-107.
17. Gohel, M.C., 2009. Application of simplex lattice design and desirability function for the formulation development of mouth dissolving film of salbutamol sulphate. Current Drug Deliv. 6, 486-494.