Volume : 13, Issue : 11, November – 2026
Title:
FORMULATION AND EVALUATION OF DELAYED DRUG RELEASE OF DALFAMPRIDINE
Authors :
Kadavergu Shreya, I.Nagaraju, Dr. K. Ramesh, G. Vijaya Kumar
Abstract :
The present study aimed to develop and evaluate a delayed drug release formulation of Dalfampridine to achieve controlled and prolonged drug release. A total of eight formulations (D1–D8) were prepared using different polymers and polymer ratios. Formulations D1 to D4 were prepared using Eudragit S100 as the polymer, while D5 to D8 were formulated using Hydroxypropyl Methylcellulose (HPMC) in varying concentrations to study their effect on the drug release profile.
All the prepared formulations were evaluated for pre-compression parameters such as bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose to assess the flow properties of the powder blend. The compressed tablets were further evaluated for post-compression parameters including hardness, friability, weight variation, thickness, and drug content. The results indicated that all formulations complied with the Indian Pharmacopoeia (IP) limits, indicating good tablet quality and uniformity.
In-vitro dissolution studies were carried out to determine the drug release behaviour of the formulations. Among all the formulations, D4, containing Eudragit S100 in an optimized ratio, showed the best drug release profile with 99.68% drug release over 12 hours. Therefore, D4 was considered as the optimized formulation due to its satisfactory physicochemical properties and controlled drug release characteristics.
The study concludes that the formulated delayed release tablets of Dalfampridine using Eudragit S100 can effectively provide prolonged drug release and may enhance therapeutic efficacy and patient compliance.
Keywords: Dalfampridine, Eudragit S100, Hydroxypropyl Methylcellulose (HPMC).
Cite This Article:
Please cite this article in press Kadavergu Shreya et al., Formulation And Evaluation Of Delayed Drug Release Of Dalfampridine.,. Indo Am. J. P. Sci, 2026; 13(11).
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