Volume : 13, Issue : 11, November – 2026

Title:

PHYTOCHEMICAL SCREENING AND PHARMACOLOGICAL EVALUATION OF ANTI DIABETIC ACTIVITY OF PANAX GINSENG PLANT EXTRACTS IN ALLOXAN INDUCED DIABETIC RATS

Authors :

G Kruthika Reddy*, Dr. Neelam I, Dr. Gampa Vijaya Kumar

Abstract :

Diabetes mellitus is a most common endocrine disorder, affecting more than 300 million people worldwide. For these therapies developed along the principles of allopathic are often limited in efficacy, Carry the risk of adverse effects, and are often too costly, especially for the developing world. In order to identify complementary or alternative approaches to existing medications, we studied the anti-diabetic potential of leaves of Panax Ginseng. The acute oral toxicity studies of the extracts revealed no toxic effects up to the levels of 2000mg/kg b.wt. The alcoholic extracts of 20 and 30mg/kg body weight of Panax Ginseng was screened for the presence of hypoglycemic and antidiabetic activity. In this study diabetes was induced by a single IP dose Alloxan monohydrate in 72hrs fasted rats. The FBGL was carried on 7th, 14th and 21st day and OGTT was measured on 8th, 15th and 22nd day. Glibenclamide was taken as the standard and the results are quite comparable with it. The studies were indicated that the leaves of Panax Ginseng are effective in regeneration of insulin secreting β-cells and thus possess antidiabetic activity. The alcoholic extracts showed significant effect in decreasing the Fasting blood Glucose level and oral glucose tolerance test of rats and it’s also showed good hypoglycemic activity in normal glycemic rats. The preliminary phytochemical analysis of the extracts of Panax Ginseng revealed the presence of Alkaloids, Tannins, Anthraquinones, Flavonoids, Saponins, Triterpenes, Sterols, Coumarin as the possible biologically active principles.
Keywords: Panax Ginseng, Alloxan monohydrate, Glibenclamide, FBGL and OGTT.

Cite This Article:

Please cite this article in press G Kruthika Reddy et al., Phytochemical Screening And Pharmacological Evaluation Of Anti Diabetic Activity Of Panax Ginseng Plant Extracts In Alloxan Induced Diabetic Rats.,. Indo Am. J. P. Sci, 2026; 13(11).

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