Volume : 08, Issue : 12, December – 2021
Title:
46.DIABETES AND RENAL IMPARMENT (PREVALENCE, RISK FACTORS) IN KSA.
Authors :
Dr. Fatima Ibrahim Albeladi, Dr. Lubna Abdulrahman hafiz, Dr. Kawthar Abdullah Al Muhandir, Dr. Hussam ateeq alsamiri , Dr. Mohammad Saleh Alzughaibi , Dr. Rabbaa Mohammed Almuyidi , Dr. Basil Abdulaziz R almutairi , Dr.Adel Hammed Alshammari , Dr. Sultan ahmed alanssari , Dr. Saad Omar Alsaab , Dr. Wejdan Ali Alshehri , Dr. Walaa Jamal Bakhashwain , Dr. Hassan Yousef Al-Mohammedali , Dr. Rawan Ismail Albaloushi , Dr. Bassel Sadi M Alsulamy
Abstract :
Objective: Nevirapine (NVP) is a non nucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents for the treatment of human immunodeficiency virus disease. The present study was aimed to develop generic formulation of extended release (ER) tablets of Nevirapine anhydrous (NVP) using hydrophilic polymer. Method: Nevirapine NVP(ER) tablets were prepared by direct compression. The prepared granules were evaluated for various physicochemical parameters by official procedure and compressed in tablets. The In-vitro release profile of various batches was prepared by different technologies and has been compared with the innovator product. In-vitro release profiles of NVP from ER tablets were determined using USP apparatus type II (Paddle), 50 rpm and bath temperature 37ºC. Dissolution of tablets was carried out in 900 ml of media (phosphate buffer pH 6.8). Samples were withdrawn at predetermined time intervals up to 24 hrs and analyzed using UV detector at a wavelength of 247 nm. Conclusion: Stress stability studies indicated that the formulation is stable and In-vitro release profile study showed that formulation using wet granulation technology.
Key Words: Nevirapine, Extended Release, Euudragit, Antiretroviral
Cite This Article:
Please cite this article in press Fatima Ibrahim Albeladi et al, Diabetes And Renal Impairment (Prevalence, Risk Factors) In KSA.., Indo Am. J. P. Sci, 2021; 08(12).
Number of Downloads : 10
References:
1. Information, H., Overview, D., Problems, P., Disease, D., Disease, D. and Health, N., 2021. Diabetic Kidney Disease | NIDDK. [online] National Institute of Diabetes and Digestive and Kidney Diseases. Available at: <https://www.niddk.nih.gov/health-information/diabetes/overview/preventing-problems/diabetic-kidney-disease> [Accessed 1 April 2021].
2. National Kidney Foundation. 2021. Diabetes – A Major Risk Factor for Kidney Disease. [online] Available at: <https://www.kidney.org/atoz/content/diabetes> [Accessed 1 March 2021].
3. Uptodate.com. 2021. UpToDate. [online] Available at: <https://www.uptodate.com/contents/management-of-hyperglycemia-in-patients-with-type-2-diabetes-and-pre-dialysis-chronic-kidney-disease-or-end-stage-renal-disease> [Accessed 4 February 2021].
4. Betterhealth.vic.gov.au. 2021. Diabetes and kidney failure | betterhealth.vic.gov.au. [online] Available at: <https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/diabetes-and-kidney-failure> [Accessed 4 March 2021].
5. Al-Futaisi A, Al-Zakwani I, Almahrezi A, Al-Hajri R, Al-Hashmi L, AlMuniri A, et al. Prevalence and predictors of microalbuminuria in patients with type 2 diabetes mellitus: a cross-sectional observational study in Oman. Diabetes Res Clin Pract 2006 May;72(2):212-215. 12.
6. Oman renal data system, renal dialysis center, DGHS, Muscat, MOH.
7. Alsuwaida AO, Farag YMK, Al Sayyari AA, Mousa D, Alhejaili F, Al-Harbi A, et al. Epidemiology of chronic kidney disease in the Kingdom of Saudi Arabia (SEEK-Saudi investigators) – a pilot study. Saudi J Kidney Dis Transpl. 2010;21(6):1066–72.
8. Hosseinpanah F, Kasraei F, Nassiri AA, Azizi F. High prevalence of chronic kidney disease in Iran: a large population-based study. BMC Public Health. 2009;9:44 Available from: https://www.ncbi.nlm.nih.gov/pubmed/19183493.
9. Xia J, Wang L, Ma Z, Zhong L, Wang Y, Gao Y, et al. Cigarette smoking and chronic kidney disease in the general population: a systematic review and meta-analysis of prospective cohort studies. Nephrol Dial Transplant. 2017;32(3):475–87.
10. Bin ZS, Hossain N, Rahman M. Associations between Body Mass Index and Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients: Findings from the Northeast of Thailand. Diabetes Metab J. 2018;42(4):330–7 Available from: https://www.ncbi.nlm.nih.gov/pubmed/30136452.
11. Sweileh WM, Sawalha AF, Zyoud SH, Al-Jabi SW, Shraim NY. Prevalence of reduced renal function among diabetic hypertensive patients. Int J Physiol Pathophysiol Pharmacol. 2009;1(1):41–7 Available from: https://www.ncbi.nlm.nih.gov/pubmed/21383877.
12. Ginter E, Simko V. Global prevalence and future of diabetes mellitus. InDiabetes 2013 (pp. 35-41). Springer, New York, NY.
13. Nagasawa Y, Yamamoto R, Rakugi H, Isaka Y. Cigarette smoking and chronic kidney diseases. Hypertension Research. 2012 Mar;35(3):261-5.