Volume : 09, Issue : 06, June – 2022
Title:
18.PHYTOCHEMICAL INVESTIGATION & IN VIVO ANTI- INFLAMMATORY EFFECT OF ETHANOLIC & AQUEOUS EXTRACT OF NYMPHAEA ALBA LINN.
Authors :
Shailesh Kumar*, Reena Shende, Sailesh kumar Ghatuary, Satkar Prasad,
Maithil Prashant
Abstract :
Abstract:
Preliminary phytochemical screening of plant extracts of Nymphaea alba, showed the presence of alkaloids, flavonoids, tannins, terpenes, phenolic acid, and glycosides. This study was intended to evaluate the anti-inflammatory activity of ethanol & aqeous extract of fresh flowers of Nymphaea alba, experimentally by carrageenan induced rat paw odema method. Ethanolic and aqueous extracts which showed; best in vitro anti-inflammatory activity was screened at the dose level of 100 and 200 mg/kg p.o. Diclofenac Sodium at the dose level of 10 mg/kg was used as reference standard drug. Both the extracts showed a dose dependent significant (P < 0.05) reduction in paw edema when compared to the control, at all the time intervals and comparable to Diclofenac Sodium treated group. There is a significant (P < 0.05) percentage inhibition of paw edema, at doses of 100 and 200mg/kg, respectively, at 4th hour by aqueous extract of Nymphaea alba. Therefore, it can be inferred that the inhibitory effect of aqueous extract of Nymphaea alba on carrageenan-induced inflammation may be due to inhibition of the enzyme cyclo-oxygenase leading to inhibition of prostaglandin synthesis. The results of the present study demonstrate that aqueous extract of Nymphaea alba possess significant anti-inflammatory potential. These findings support the use of the extract in traditional.
Cite This Article:
Please cite this article in press Shailesh Kumar et al, Phytochemical Investigation & In Vivo Anti- Inflammatory Effect Of Ethanolic & Aqueous Extract Of Nymphaea Alba Linn.., Indo Am. J. P. Sci, 2022; 09(6).,
Number of Downloads : 10
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