Volume : 08, Issue : 08, August – 2021

Title:

23.NANOFIBERS – A NEW TREND IN NANO DRUG DELIVERY SYSTEMS

Authors :

Shaik Khadar Jilani*, Yeminedi Tejaswini, Uppelli Jhansi, G Ramakrishna, Yerragopu Naga Surekha

Abstract :

Polymer nanofibers, with diameters in the nanometer range, possess larger surface areas per unit mass and permit easier addition of surface functionalities compared with polymer microfibers. Hence, polymer nanofiber are being considered for use as filters, scaffolds for tissue engineering, protective clothing, reinforcement in composite materials and sensors. Although some of these applications are in the development stage, a few have been commercially exploited. Research on polymer nanofibers, nanofiber mats, and their applications has seen a remarkable growth over the last few years. Among all methods, electro spinning has been used to convert a large variety of polymers into nanofibers and may be the only process that has the potential for mass production. Although there are many methods of fabricating nanofibres, electro spinning is perhaps the most versatile process. Materials such as polymer, composites, ceramic and metal nanofibres have been fabricated using electro spinning directly or through post-spinning processes. However, what makes electro spinning different from other nanofibre fabrication processes is its ability to form various fibre assemblies. This will certainly enhance the performance of products made from nanofibres and allow application specific modifications. It is therefore vital for us to understand the various parameters and processes that allow us to fabricate the desired fibre assemblies. The structure, morphology, and geometry of nanofibers and the porosity and tensile properties of nanofiber mats can be investigated through conventional techniques and instruments.
Key Words: Nanofibers, Electro spinning, Electro spuns.

Cite This Article:

Please cite this article in press Shaik Khadar Jilani et al, Nanofibers – A New Trend In Nano Drug Delivery Systems., Indo Am. J. P. Sci, 2021; 08(8).

Number of Downloads : 10

References:

1. Hung ZM, Zhangb YZ, Kotakic M, Ramakrishna S. A review on polymer nanofibers by electro spinning and their applications in nanocomposites.Composites Science and Technology.2003; 63: 2223–2253.
2. Shin SH, Purevdorj O, Castano O, Planell JA, Kim HW. A short review: Recent advances in electro spinning for bone tissue regeneration. Journal of Tissue Engineering 3; 1-10.
3. Huanga ZM, Zhang YZ, Kotakic M, Ramakrishna S. A review on polymer nanofibers by electro spinning and their applications in nanocomposites. Composites Science and Technology 2003;63: 2223-2253.
4. Bergshoef MM, Vancso GJ. Transparent nanocomposites with ultrathin, electrospun Nylon-4,6 fiber reinforcement. Adv Mater 1999;11(16):1362–5.
5. Deitzel JM, Kleinmeyer J, Harris D, Tan NCB. The effect of processing variables on the morphology of electro spun nanofibers and textiles. Polymer 2001;42:261–72.
6. Koombhongse S, Liu WX, Reneker DH. Flat polymer ribbons and other shapes by electro spinning. J Polymer Sci: Part B: Polymer Physics 2001;39:2598–606.
7. Reneker DH, Yarin AL, Fong H, Koombhongse S. Bending instability of electrically charged liquid jets of polymer solutions in electro spinning. J ApplPhys 2000;87:4531–47.
8. Yarin AL, Koombhongse S, Reneker DH. Bending instability in electrospinning of nanofibers. J ApplPhys 2001;89(5):3018–26.
9. Yarin AL, Koombhongse S, Reneker DH. Taylor cone and jetting from liquid droplets in electrospinning of nanofibers. J ApplPhys 2001;89(9):4836–46.
10. Shin YM, Hohman MM, Brenner MP, Rutledge GC. Electro spinning: A whipping fluid jet generates submicron polymer fibers. ApplPhysLett 2001;78:1149–51.
11. Hohman MM, Shin M, Rutledge G, Brenner MP. Electro spinning and electrically forced jets. I. Stability theory. Physics of Fluids 2001;13:2201–20.
12. Hohman MM, Shin M, Rutledge G, Brenner MP. Electrospinning and electrically forced jets. II. Applications. Physics of Fluids 2001;13:2221–36.
13. Baumgarten PK. Electrostatic spinning of acrylic microfibers. J of Colloid and Interface Science 1971;36:71–9.
14. Doshi J, Reneker DH. Electrospinning process and applications of electro spun fibers. J Electrostatics 1995;35(2-3):151– 60.
15. Fong H, Chun I, Reneker DH. Beaded nanofibers formed during electrospinning. Polymer 1999;40:4585–92.
16. Deitzel JM, Kleinmeyer J, Harris D, Tan NCB. The effect ofprocessing variables on the morphology of electro spun nanofibers and textiles. Polymer 2001;42:261–72.
17. Demir MM, Yilgor I, Yilgor E, Erman B. Electro spinning of polyurethane fibers. Polymer 2002;43:3303–9.
18. Bognitzki M, Czado W, Frese T, Schaper A, Hellwig M, Steinhart M, et al. Nanostructured fibers via electrospinning. AdvMater 2001;13:70–2.
19. Hu, J.L., Huang, J.H., Chih, Y.K., Chuang, C.C., Chen, J.P., Cheng, S.H., Horng, J.L. (2009).Diamond & Related Materials, 18., 511–515, 0925-9635
20. Im, J.S., Park, S.J., Lee, Y.S., (2009). The metal–carbon–fluorine system for improvinghydrogen storage by using metal and fluorine with different levels ofelectronegativity.International Journal of Hydrogen Energy, 34(3), 1423-1428, 0360- 3199
21. Im, J.S., Park, S.J., Lee, Y.S., (2009). Superior prospect of chemically activated electrospun carbon fibers for hydrogen storage.Materials Research Bulletin, 44(9), 1871-1878, 0025-5408
22. Heintze, M., Bru¨ser, V., Brandl, W., Marginean, G., Bubert, H., Haiber, S. (2003). Surface and Coatings Technology, 174 –175., 831–834, 0257-8972
23. Im, J.S., Yun, J., Lim, Y.M., Kim, H.I., Lee, Y.S. (2009). Fluorination of electrospun hydrogelfibers for a controlled release drug delivery system.ActaBiomaterialia, In Press, 1742-7061
24. Im, J.S., Yun, J., Lim, Y.M., Kim, H.I., Lee, Y.S. (2009). Fluorination of electrospun hydrogelfibers for a controlled release drug delivery system.ActaBiomaterialia, In Press, 1742-7061
25. Chand S. Review: carbon fibers for composites. J Mater Sci 2000;35:1303–13.
26. Bergshoef MM, Vancso GJ. Transparent nanocomposites with ultrathin, electrospun Nylon-4,6 fiber reinforcement. Adv Mater 1999;11(16):1362–5.
27. Suthat A, Chase G. Chemical Engineer 2001:26–8.
28. Tsaia PP, Schreuder-Gibson H, Gibson P. Different electrostatic methods for making electrets filters. Journal of Electrostatics 2002;54:333–41.
29. Graham K, Ouyang M, Raether T, Grafe T, McDonald B, Knauf P. Fifteenth Annual Technical Conference & Expo of the American Filtration & Separations Society, Galveston, TX; 9– 12 April 2002.
30. Laurencin CT, Ambrosio AMA, Borden MD, Cooper Jr JA. Tissue engineering: orthopedic applications. Annu Rev Biomed Eng 1999;1:19–46.
31. Buchko CJ, Chen LC, Shen Y, Martin DC. Processing and Micro structural characterization of porous biocompatible protein Polymer thin films. Polymer 1999;40:7397–407.
32. Fertile A, Han WB, Ko FK. Mapping critical sites in collagen II for rational design of gene-engineered proteins for cell-supporting materials. J Biomed Mater Res 2001;57:48–58.
33. Huang L, McMillan RA, Apkarian RP, Pourdeyhimi B, ConticelloVP, Chaikof EL. Generation of synthetic elastin-mimetic small diameter fibers and fiber networks. Macromolecules 2000;33(8):2989–97.
34. Coffee RA. PCT/GB97/01968, 1998.
35. Jin HJ, Fridrikh S, Rutledge GC, Kaplan D. Electro spinning Bombyxmorisilkwith poly(ethylene oxide). Abstracts of Papers American Chemical Society 2002;224(1–2):408.
36. Martindale D. Scientific American 2000:34–6.
37. Smith D., Reneker DH. PCT/US00/27737. 2001.
38. Smith D, Reneker DH,Schreuder GH, Mello C, Sennett M, Gibson P. PCT/US00/27776, 2001.
39. www.ecmjournal.org
40. www.zapmetd.com