Volume : 08, Issue : 08, August – 2021

Title:

32.SPECTROPHOTOMETRIC METHOD DEVELOPMENT FOR ESTIMATION OF TERIFLUNOMIDE IN DOSAGE FORM

Authors :

Binal Patel*, Krima Patel*, Hardi Prajapati*, Disha Chudhary *, Mrs. Khushbu K. Patel1*, Dr. C. N. Patel

Abstract :

Objective: The objective of the work was to develop a simple suitable spectrophotometric method for estimation of Teriflunomide in Pharmaceutical dosage forms.
Method: Simple UV Spectrophotometric methods was developed for estimation of Teriflunomide in pharmaceutical dosage form by measuring absorbance at maximum at 200 – 400 nm. The method has been validated as per ICH guidelines.
Result and discussion: UV Spectrophotometric method showed good linearity from 2-12 µg/mL the method has been validated as per ICH guidelines. Accuracy (% recovery) for zero order (101.46%-99.93 %) and for first order (101.56%-99.72%). The limit of detection (LOD) for zero order was found to be 0.565µg/mL and for first order was found to be 0.816 µg/mL while the limit of Quantitation (LOQ) for zero order was found to be 1.713µg/mL and for first order was found to be 2.472 µg/mL.
Conclusion: The developed Spectrophotometric methods were validated as per ICH guideline and can be used for routine analysis of Teriflunomide in Pharmaceutical dosage form.
Key words: Teriflunomide, UV Visible Spectrophotometric method, Derivative Spectroscopy, Method Validation, ICH Guidelines

Cite This Article:

Please cite this article in press Khushbu K Patel et al., Spectrophotometric Method Development For Estimation Of Teriflunomide In Dosage Form., Indo Am. J. P. Sci, 2021; 08(08).

Number of Downloads : 10

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