Volume : 08, Issue : 08, August – 2021
Title:
49.EFFECTS OF ANTI-HISTAMINE ON MOOD
Authors :
Amna Ayed Asiri, Sultan Abdulrahman Alghamdi, Ashwag yahya Mohammed Aoun, Hanan Mohamed Alkhuwayldi, Rana Abdullah Abdulhadi, Moataz Abdullah Alghamdi, Moath Salah Odhiman, Afaf Abdullah Alshehri
Abstract :
Introduction: Antihistamines are the mainstay of treatment for allergic disorders. Anti-histamines are broadly classified as first-generation antihistamines and second-generation antihistamines. These agents are effective H1-receptor antagonists and highly lipophilic and readily cross the blood-brain barrier, causing a considerable amount of sedation. The second-generation agents are more lipophobic in nature and possess different ionic charges than the first-generation antihistamines. This makes them less likely to cross the blood-brain barrier causing little sedation. Patients treated with the first-generation agent diphenhydramine were found to have significant performance deficits on tests of divided attention, working memory, vigilance, and speed compared to those with the second-generation antihistamine. The sedative effects of the first-generation agents persist well into the next day and thus can potentially interfere with daytime performance and safety even when taken the night before. It is therefore recommended that patients whose occupations require vigilance, divided attention, or concentration receive only second-generation antihistamines.
Aim of the study: The aim of the present view is to assess the effects of anti-histamine on mood.
Methodology: The review is a comprehensive research of PUBMED since the year 1998 to 2014
Conclusion
Keywords: Antihistamines first-generation, antihistamines second generation, sedation, working memory.
Cite This Article:
Please cite this article in press Amna Ayed Asiri et al., Effects Of Anti-Histamine On Mood.., Indo Am. J. P. Sci, 2021; 08(08).
Number of Downloads : 10
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