Volume : 08, Issue : 12, December – 2021
Title:
30.RECENT ADVANCES IN ULTRASOUND-CONTROLLED FLUORESCENCE TECHNOLOGY FOR DEEP TISSUE OPTICAL IMAGING: A REVIEW
Authors :
Sonam Sasi*, Subhash Chandran M P, Dr. Prashob G R, Shilpa Suresh
Abstract :
Fluorescence imaging is a non-invasive and dynamic real-time imaging technique; however, it exhibits poor spatial resolution in centimetre-deep tissues because biological tissues are highly scattering media for optical radiation. The recently developed ultrasound-controlled fluorescence (UCF) imaging is a novel imaging technique that can overcome this bottleneck. Previous studies suggested that the effective contrast agent and sensitive imaging system are the two pivotal factors for generating high-resolution UCF images ex vivo and/or in vivo. Here, this review highlights the recent advances (2015–2020) in the design and synthesis of contrast agents and the improvement of imaging systems to realize high-resolution UCF imaging of deep tissues. The imaging performances of various UCF systems, including the signal-to-noise ratio, imaging resolution, and imaging depth, are specifically discussed. In addition, the challenges and prospects are highlighted. With continuously increasing research interest in this field and emerging multidisciplinary applications, UCF imaging with higher spatial resolution and larger imaging depth may be developed shortly, which is expected to have a far-reaching impact on disease surveillance and/or therapy.
Keywords : Ultrasound-controlled fluorescence imaging, Temperature-sensitive NIR probes, High-resolution, Deep tissue, Molecular diagnosis.
Cite This Article:
Please cite this article in press Sonam Sasi et al, Recent Advances In Ultrasound-Controlled Fluorescence Technology For Deep tissue optical imaging: a review ., Indo Am. J. P. Sci, 2021; 08(12).
Number of Downloads : 10
References:
1. J. Qi, C. Sun, D. Li, et al. Aggregation-induced emission luminogen with near-infrared-II excitation and near infrared-I emission for ultra-deep intravital two-photon microscopy.ACS Nano, 12 (2018), pp. 7936-7945.
2. S. He, J. Song, J. Qu, et al. Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics. Chem. Soc. Rev., 47 (2018), pp. 4258-4278.
3. E. Hemmer, A. Benayas, F. Legare, et al. Exploiting the biological windows: current perspectives on fluorescent bioprobes emitting above 1000 nm Nanoscale Horiz, 1 (2016), pp. 168-184.
4. S. Yu, D. Tu, W. Lian, et al. Lanthanide-doped near-infrared II luminescent nanoprobes for bioapplications. Sci. China Mater., 62 (2019), pp. 1071-1086.
5. D. Kim, N. Lee, Y. Park, et al. Recent Advances in inorganic nanoparticle-based NIR luminescence imaging: semiconductor nanoparticles and lanthanide nanoparticle. Bioconjugate Chem., 28 (2017), pp. 115-123.
6. G. Hong, A.L. Antaris, H. Dai. Near-infrared fluorophores for biomedical imaging. Nat. Biomed. Eng., 1 (2017), Article 0010.
7. J.A. Carr, D. Franke, J.R. Caram, et al. Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine greenProc. Natl. Acad. Sci. U.S.A., 115 (2018), pp. 4465-4470
8. J.V. Frangioni. In vivo near-infrared fluorescence imaging. Curr. Opin. Chem. Biol., 7 (2003), pp. 626-634.
9. B. Yuan, Y. Liu, P. Mehl, et al. Microbubble-enhanced ultrasound modulated fluorescence in a turbid medium Appl. Phys. Lett., 95 (2009), p. 181113.
10. N.T. Huynh, B.R. Hayes-Gill, F. Zhang, et al. Ultrasound modulated imaging of luminescence generated within a scattering medium J. Biomed. Opt., 18 (2013), p. 20505.