Volume : 08, Issue : 12, December – 2021

Title:

33.FORMULATION OF BUPROPION HYDROCHLORIDE EXTENDED-RELEASE TABLET DOSAGE FORM

Authors :

Divya.T*, Suresh Kumar.P, Jagannath Patro.V, Sunitha. CH, Vanitha.S

Abstract :

The objective of the present investigation is to design and evaluate extended-release dosage form of bupropion hydrochloride and compare with innovator product (Wellbutrin extended-release tablets). Extended-release tablets were prepared by wet granulation method using HPMC and Microcrystalline Cellulose as matrixing agents. The granules prepared were shown satisfactory flow properties and compressibility. Prepared Granules were evaluated for Angle of repose, bulk density, tapped density, compressibility index, Hausner ratio. The granules shown satisfactory flow properties and compressibility. Tablets were tested for weight variation, thickness, hardness, friability and in vitro drug release as per official procedure. . Formulation of Extended-release tablet of bupropion hydrochloride as formulation batches F-1 and F-2 with a variation in the quantities of HPMC and Microcrystalline indicated that the formulation F-II be taken as an ideal or optimized formulation resembling the marketed product of Wellbutrin sustained release tablets for 10-hour release as it full fills all the requirements for sustained release tablet.
Keywords: Extended-release Tablets, bupropion hydrochloride, Hydroxy propyl methyl cellulose, Microcrystalline Cellulose, dissolution.

Cite This Article:

Please cite this article in press T. Divya et al, Formulation Of Bupropion Hydrochloride Extended-Release Tablet Dosage Form., Indo Am. J. P. Sci, 2021; 08(12).

Number of Downloads : 10

References:

1. Lee TWY, Robinson JR., 20th ed, 2000. Remington: the science and practice of pharmacy, 1069-70. Lippincott Williams and Wilkins, Maryland.
2. Loyd V. Allen J, Nicholas G. Popovich, Howard C. Ansel, 8th ed, 2006. Ansel: pharmaceutical dosage forms and drug delivery system, 260-275. Lippincott Williams and Wilkins, Philadelphia.
3. Saptarshi D, Mukul S., 2009. Modified release dosage form and drug delivery. J pharm research, 2(11):1728-29.
4. Jain NK., 2000. Advances in controlled and Novel Drug Delivery, 268-269. CBS publications, New Delhi.
5. Drug delivery, 1991. Available from: URL: www.wikipedia.org
6. Robinson JR, Lee VH., 2nd ed, 1987. Controlled drug delivery: fundamentals & application, 36. Marcel Dekker, New York (NY).
7. Chein YW., 2nd ed, 1992. Novel drug delivery systems, 2, 36, 140-141, 484. Marcel Dekker, Newyork (NY).
8. Howard C. Ansel, Loyd V. Allen, Nicholas G. Popovich., 2000. Ansel’s Pharmaceutical Dosage forms and Drug Delivery Systems, 268.
9. Schwartz BJ., 2000. Pharmaceutical Dosage Forms: Tablets. 75-130. Marcel Dekker, New York.
10. Aulton M.E, international student Edition, 2001. Pharmaceutics-The Science of Dosage form design, 129-191. Churchill Livingston.
11. Leon Lachman, Joseph L, Kanig., 3rd ed, 1986. The theory and practice of industrial pharmacy, 331-2, 364-8. Lea & Febiger, Philadelphia.