Volume : 08, Issue : 02, February – 2021
05.DIAGNOSTIC PROGNOSTIC AND THERAPEUTIC ROLE OF MICRORNA IN CARDIOVASCULAR DISEASES
Jamila Begum Jabar Ali, Baraqah Abdul Kareem, Noha Elnoor Ahmed Elzaki, Salma Mohammed Alfatih Mansour Alsedeeg, Doaa Osama Suliman Mohammed
Abstract :
Cardiovascular diseases are the main cause of death in the global world and are associated with increasing financial expenses. By the availability of next-generation sequencing technologies since the early 2000s, non-coding RNAs such as microRNAs, long non-coding RNAs and circular RNAs have been recognized as therapeutic target for many diseases, including cardiovascular diseases. In this Review, we will summarize current approaches to screen for novel coding and non-coding RNA candidates with diagnostic and therapeutic potential in cardiovascular disease, including next-generation sequencing, functional high-throughput RNA screening and single-cell sequencing technologies. We highlight viral-based delivery tools that have been widely used to evaluate the therapeutic utility of both coding and non-coding RNAs in the context of cardiovascular disease. Finally, we discuss the potential of using oligonucleotide-based molecular products such as modified RNA, small interfering RNA and RNA mimics/inhibitors for the treatment of cardiovascular diseases. The number of potential RNAs diagnostic and therapeutic targets for cardiovascular diseases will continue to expand for years to come.
Keywords: microRNA; cardiovascular diseases; myocardial infarction; atherosclerosis; heart failure
Cite This Article:
Please cite this article in press Jamila Begum Jabar Ali et al, Diagnostic Prognostic And Therapeutic Role Of Microrna In Cardiovascular Diseases., Indo Am. J. P. Sci, 2021; 08(02).