Volume : 08, Issue : 02, February – 2021
25.FORMULATION AND DEVELOPMENT OF ANTIFUNGAL LOADED NANOEMULGEL FOR THE TREATMENT OF ONYCHOMYCOSIS
Sruthi.S and Roma Mathew
Abstract :
Nanoemulgel has emerged as one of the most interesting topical delivery systems as it has dual release control system i.e nanoemulsion and hydrogel. Nanoemulgel having nanosize (below 200nm) rapidly penetrates and deliver the active substance deeper and quicker. This work was aimed to develop and evaluate nanoemulgel based transungual drug delivery system of poorly water soluble efinaconazole with better drug release for the treatment of onychomycosis. Efinaconazole has been shown to have a more potent antifungal activity in vitro than the most commonly used onychomycosis treatments. The low keratin affinity of the efinaconazole contributes to its effective delivery through nail plate and retention of its antifungal activity. Characterization of drug and excipients were performed and FTIR results confirmed the compatibility of efinaconazole with the excipients. Pseudoternary phase diagram were constructed using titration method to figure out the ratio of Smix. Nanoemulsion containing efinaconazole was prepared by spontaneous emulsification method using, Triacetin as oil, Tween 80 as surfactant and Transcutol as co surfactant. Carbopol 934 is used as the gelling agent.Thiogylcollic acid is incorporated as the penetration enhancer. Prepared nanoemulgel was evaluated for physical appearance, pH, viscosity, particle size, drug release. In vitro drug release study was performed for efinaconazole nanoemulgel and it showed better release profile compared to plain gel. It showed that 50% of the drug is released in the 8th hour. Thus more than 90% drug release will occur by 24th hour which indicate good controlled release. The kinetic modelling confirmed Non fickian or anomalous diffusion of efinaconazole from nanoemulgel.
KEYWORDS: Nanoemulgel,Onychomycosis,Efinaconazole, Transungual drug delivery system,solubility
Cite This Article:
Please cite this article in press Sruthi.Sand Roma Mathew, Formulation And Development Of Antifungal Loaded Nanoemulgel For The Treatment Of Onychomycosis.,Indo Am. J. P. Sci, 2021; 08(02).