Volume : 08, Issue : 02, February – 2021

43.EMULGEL – NOVEL TOPICAL DRUG DELIVERY SYSTEM: A REVIEW

Rohini L M*, Subash Chandran M P, Dr. Prasobh G R, Varsha V R, Archana L R, Blessy M R

Abstract :

Emulgel systems are currently of attention to the pharmaceutical scientists because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules. These are either emulsion of water in oil type or oil in water, which is gelled by mixing it with a gelling agent. Incorporation of emulsion into gel makes it a dual control release system & also increases its stability. Due to lack of insoluble excipients and excess oily bases, it demonstrates better drug release as compared to other topical drug delivery system. Due to nongreasy because of the presence of gel phase which favors good patient compliance. In order to understand the potential of emulgel as delivery vehicles, this review gives an overview of the ideal properties, formation, and characterization of emulgels. The use of emulgel -based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions. In comparison with the other semisolid formulations, the use of gels seems to be more advantageous both in cosmetics and pharmaceutical preparations. When gel and emulsion are used in the combined form, they are referred as emulgel. Emulgel is the promising drug delivery system for the delivery of hydrophobic drugs. Emulgel, an interesting topical drug delivery system, has dual release control system, i.e., gel and emulsion. Emulgel have several merits like greaseless, easily spreadable, easily removable, emollient and transparency. Preparation of emulgel is done by incorporation method. Emulgel are commonly used for the delivery of analgesics, anti-inflammatory, anti-fungal, anti-acne drugs and various cosmetic formulations. Studies on emulgel promises a better future in delivering more numbers of topical drugs as emulgel by their merits over other drug delivery systems.
Keywords: Emulgel, Gelling agent, Emulsion, Topical agents

Cite This Article:

Please cite this article in press Rohini L M et al, Emulgel – Novel Topical Drug Delivery System:
A review., Indo Am. J. P. Sci, 2021; 08(02).

Number of Downloads : 10

References :

References :

1. Ahiraro S P, Raut T S, Nikam A S et al. Emulgel: A Novel approach for delivery of hydrophobic drugs. Int J Pharma Res Sch.2015;4(2):152-160.
2. Kokane V, Naik S. Formulation and evaluation of topical Flubiprofenemulgel using different gelling agents. World J Pharm Pharm Sci. 2014; 3(9): 654-663.
3. Shailendra P, Sayantan M. Formulation and evaluation of Tioconazoleemulgel for topical drug delivery system. Am. J. Pharm Tech res. 2015; 5(6): 2249-3387.
4. Kalpana B, Ganesh B. Nanoemulgel: A novel formulation approach for topical deliverey of hydrophobic drugs. World J Pharm Pharm Sci. 2015; 4(10): 18711886.
5. Davinder K, Jasbir S. Emulgel: novel topical drug delivery system: a comprehensive review. Int J Pharm Sci Res. 2016; 7(12): 4733-4742.
6. Anu H, Sonali J, Sanjay J. Emulgel: An emergent tool in topical drug delivery. Int J Pharm Sci Res. 2014;5(5):1653-1660.
7. Reha C, Asish D. Formulation and Characterisation of Triamcinolone Acetonideemulgel.Wrld J Pharm Pharma Sci.2017;6(7):1795-1810
8. Wesley Z. D’Souza, Rajashree G et al. Formulation, design, development and evaluation of emulgel for topical delivery of meloxicam in the treatment of rheumatoid arthritis.IndoAmerca J Pharm Pharma Res. 2015;5(3):1271-1279.
9. Mohammed K P, Guru P M, Chandini N et al. Emulgel: An Advanced Review.2013;5(12):254-258.
10. Shailendra K S, Ashutosh B, Bipin K N et al. Emulgel: Magnifying the application of topical drug delivery. Indian J Pharma Bio Res.2017;5(1):25-33.
11. Sehal P, Mulye, Kiran A. Formulation and evaluation of Indomethacin emulgel. Der pharmacia sinica.2013;4(5):31-45.
12. Sonali M, Teena O. Formulation and evaluation of Mefanamic acid emulgel. Int j pharma res devlpmnt.2014;5(12):091-100
13. Khuriah A H, Salizatul I I, Muhammad A H. Formulation and evaluation of Benzyl benzoate emulgel. IOSR j pharm bio Sci.2015;10(3):06-09
14. Navaneetha K, Asma B, Sumalatha P et al. Formulation and evaluation of capsaicin emulgel for topical drug delivery. SchAcad J Pharm.2017;6(6):281-287.
15. RangaPriya M, Sellakumar V, Natarajan R et al. Formulation and in vitro evaluation of Ciprofloxacin emulgel for topical drug delivery. Int J PhrmaChem Sci.2012;1(1):237-241.
16. Ramakanth A, Sateesh K V. Formulation and characterization of Ketoprofenemulgel.J Applied Pharma Sci.2015;5(7):112-117.
17. Vijay K, Sheefali M, Rekha R et al. Emulgel based topical delivery system for Loratidine. ADMET & DMPK.2014;2(4):254-271.
18. Dhobale S, Shelke G, Jadhav S et al. Formulation and evaluation of Luliconazoleemulgel for topical drug delivery. Int Res J Sci Eng.2018;3(10):85-90
19. Dignesh M K, Ashish D. Mishra, Dinesh R S. Formulation design and development of Piroxicamemulgel. Int J Pharm Tech Sci.2012;4(3):1332-1334. Bhautik K, Dipti G, Dinal P et al.
20. Formulation and Evaluation of Spironolactone Loaded Emulgel for Topical Application. J Pharma Bio Sci Res. 2016;6(5):740-752
21. Ghada E Y. Formulation and Evaluation of Optimized ClotrimazoleEmulgel Formulation. Bri J Pharma Res.2014;4(9):1014-1030.
22. Kumari L A, Aniket S, Saurabh S S et al. Formulation and evaluation of Lycopene emulgel. Indo Ame J Pharma Sci.2015;2(6):1013-1027.
23. Pottalaswathi1, Kiran V. Formulation and evaluation of Aceclofenacemulgel. Int J AdvncPharma Sci.2015;3(1):52-57.
24. Chemate S Z, Rahul M A . Formulation and evaluation of Terbinafine hydrochloride film forming emulgel. Int. J. Drug Res. Tech. 2016;6(3):164- 175
25. VijayaBhanu KP. Development and optimization of novel Diclofenacemulgel for topical drug delivery.Int J Comp Pharm. 2011;2(1):1- 4