Volume : 08, Issue : 01, January – 2021
5. INCIDENCE OF GASTROESOPHAGEAL REFLUX DISEASE RELATE WITH HUMAN LEUKOCYTE ANTIGEN HLA-DRB1
Dr. Utsav Bhattarai, Dr. Rohit Murarka, Dr. Madan Giri
Background: Gastro Esophageal Reflux Disease (GERD) is characterized by various symptoms. There is evidence for a genetic component of gastro-esophageal reflux disease, confirmed by familial aggregation of the disease. The aim of the study was to investigate whether certain genes of human leukocyte HLA-DRB1 antigens are associated with (GERD).
Methods: Patients and controls were prospectively recruited from the Gastroenterology department of Dhulikhel Hospital Kavre District, Nepal for one-year duration from March 2019 to March 2020. Sixty patients with a history of heartburn and indigestion were compared with 100 controls. All studied patients and control groups underwent endoscopic examination of the upper gastrointestinal tract, and their sera were analyzed for CagA Immunoglobulin G (IgG) antibodies to H. pylori. HLA-DRB1 genotyping was performed in both groups.
Results: A total of 60 patients with erosive gastritis; GERD was assessed (grade II and III) along with 100 controls. There is a significant increase in H. pylori infection (p = 0.0001) in patients with GERD than in the control group. HLA-DRB1 * 15: 01 was significantly increased in patients with GERD compared to the control group and the increased frequency of HLADRB1 * 11: 01 in the control group compared to the group of patients.
Conclusions: There is an association between HLA-DRB1 * 15: 01 in GERD and H pylori positive patients.
Keywords :HLA, GERD, H pylori.
Cite This Article:
Please cite this article in press Utsav Bhattarai et al, Incidence Of Gastroesophageal Reflux Disease Relate With Human Leukocyte Antigen Hla-Drb1., Indo Am. J. P. Sci, 2021; 08(1).
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