Volume : 08, Issue : 01, January – 2021
37. A REVIEW OF UV CURABLE GEL FOR NAIL DISEASES
Mariya Thomas, Soja A
Nail diseases are common, cause significant distress and treatments are not much successful. The nail unit can be subjected to numerous disorders, some of which, for example , onychomycosis (fungal nail infection) and psoriasis , are often extremely painful, recalcitrant to treatment , and result in psychosocial and occupational consequences, reducing a person’s quality of life. Current treatments include topical and oral antifungals. Oral therapy has the inherent disadvantages of systemic adverse effects , drug interactions and contraindications . Topical therapy , on the other hand, has a very low success rate. But ,in comparison with all these therapies ,UV curable gel formulations could act as a drug depot on the nail plate. The formulations typically contain three major components: a urethane methacrylate based monomer (at 75- 85% w/w ) ,(meth)acrylate based monomer (at 15-25% w/w ) and a polymerisation photo initiator (at 1- 3% w/w ). Following application of the formulation on the nail plate surface , the nail is placed under a UVA lamp for approximately 2 minutes . The UVA lamp light initiates polymerisation and a glossy , cosmetically acceptable polymeric film is developed on the nail plate . The film has long residence on the nail plate and such a film could be used as an effective drug carrier to improve the topical therapy of nail diseases.
Keywords : nail disease; topical therapy; UV curable gel; drug depot; UVA lamp.
Cite This Article:
Please cite this article in press Mariya Thomas et al, A Review Of UV Curable Gel For Nail Diseases., Indo Am. J. P. Sci, 2021; 08(01).
Number of Downloads : 10