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Volume : 08, Issue : 01, January – 2021
422.FORMULATION AND EVALUATION OF MOUTH DISSOLVING DRUG DELIVERY OF WAFER FOR THE TREATMENT OF ALLERGIC DISORDER
Ashuthosh Badola, Neha
Abstract :
The lyophilized wafer developed throughout this review is an effective and versatile drug delivery system for or mucosal application. This has been established from the extensive physicochemical and physic mechanical profiling conducted. Through a screening and selection of polymers, HPC had the lowest gelatin characteristics and was therefore suitable for the development of the wafer system. Suitable excipients and polymer combinations were established which allowed for the development of rapidly disintegrating and prolonged release wafer systems. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin caramelizes and gelatin, provided effective release of model drug di-phenhydramine hydrochloride over approximately six hours. The modification of this technology to provide a prolonged release mucoadhesive system seems promising. It is envisaged that this system will be applicable to many drugs requiring the extended release of bioactive material. Therefore, the lyophilized wafer matrices developed in this study are highly effective in the rapid delivery of drugs, using the oral route as a site of administration.
Keywords: Glioblastoma, glycospingolipids, acylceramides, matrices and lyophilized.
Cite This Article:
Please cite this article in press Ashuthosh Badola et al, Formulation And Evaluation Of Mouth Dissolving Drug Delivery Of Wafer For The Treatment Of Allergic Disorder., Indo Am. J. P. Sci, 2021; 08(1).