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Volume : 08, Issue : 01, January – 2021
428.FORMULATION AND CHARACTERIZATION OF GLICLAZIDE LOADED NANOGEL FOR TREATMENT OF DIABETES MELLITUS TYPE-2
S. Mukhopadhyay*, Pragati Trivedi
Abstract :
Gliclazide is a weak acid compound with high lipophilicity and has pH-dependent solubility. The drug is insoluble under acidic condition in the stomach, when consumed orally causes several side effects namely heartburn, anorexia, nausea and ulcer This leads to reduced patient compliance and in turn reduces drug efficacy. Topical drug delivery are potential routes for a variety of drugs with limited oral bioavailability. Nanogel formulations are efficient in enhancing the delivery of such drugs. Incorporating drug in the form of nanogel has potential in enhancing the poorly permeable drug for topical drug delivery. It showed promising results on delivering also showed a superiority based on its retention and adhesive properties for better absorption. In the report, a nanogel was developed and evaluated as a platform for topical drug delivery. We have prepared gliclazide nanogel at different drug polymer ratios. The particle size polydispersity retention viscosity were evaluated F2 and F4 showed higher releasing rate compared to F1 On the other hand, F1 showed higher skin permeation. Gliclazide nanogel formulation with ethanol as a penetration enhancer demonstrated a pronounced effect on enhancing Gliclazide skin permeability and content upon topical application. Based on these results, this study is further directed to choose a model for diabetes mellitus type 2 as a therapeutic tool.
Keywords: Nanogel, Nanotechnology, Gliclazide, topical drug delivery
Cite This Article:
Please cite this article in press S. Mukhopadhyay et al, Formulation And Characterization Of Gliclazide Loaded Nanogel For Treatment Of Diabetes Mellitus Type-2., Indo Am. J. P. Sci, 2021; 08(1).