Volume : 08, Issue : 07, July – 2021
Title:
05.FORMULATION DESIGN AND IN VITRO EVALUATION OF VILDAGLIPTIN MUCOADHESIVE MICROSPHERES
Authors :
A. V. S. Himabindu*, M. Manasa, N. Neeraja, M. J. L. Manasa Reddy, B. Umadevi,S. Umamaheswari, K. Padmalatha
Abstract :
The main aim of the present work was to formulate and characterize oral sustained release mucoadhesive microspheres of Vildagliptin. Vildagliptin is a dipeptidyl peptidase IV (DPP-IV) inhibitors used in the management of diabetes. This drug also undergoes first-pass metabolism. To overcome this problem Vildagliptin mucoadhesive microspheres were developed to control the release rate of the drug and target to the specific site of the body to make an enormous impact in the formulation and development of novel drug delivery system and also improve efficient absorption and enhances oral bioavailbility of the drug due to high surface to volume ratio. It also provides an intimate contact of the drug delivery system to the absorbing mucous membrane for sustaining the drug action. This is a new oral drug delivery system which was developed and utilized both the concepts of sustained release and mucoadhesiveness in order obtain a unique drug delivery system which could remain in intestine and control the drug release for longer period of time.
Key words: mucoadhesive, bioavailability, sustained release
Cite This Article:
Please cite this article in press A. V. S. Himabindu et al., Formulation Design And In Vitro Evaluation of Vildagliptin Mucoadhesive Microspheres.., Indo Am. J. P. Sci, 2021; 08(07)..
Number of Downloads : 10
References:
1. Modi S A, Gaikwad P D, Banker V H, Pawar S P; Sustained release drug delivery system a review, Int. J. Pharm Res Dev. 2011, 2(12): 147-160.
2. Mitra A. and Dey B.; Chitosan microspheres in novel drug delivery system, Indian Journal of Pharmaceuticals Sciences, 2011, 73(12): 355-366.
3. Prasanth V.V, Moy A C, Mathew M, Mathapan R; Microspheres-An Overview, Int. J. Res. Pharm. Biomedical Sci. 2011, 2(2), 23-29.
4. Chen X, Wen H, Park K; Challenges and new technologies of oral controlled release, Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice, Chapter-16 2010, 257-277.
5. Reddy KR., Mutalik S, Reddy ;Modified drug delivery system, AAPS Pharm. Sci. Tech. 2003, 4(3): 1-9.
6. Venkatraman S, Davar A, Chester A, Kleiner L, Wise DL; An overview of controlled release systems, Handbook of Pharmaceutical Controlled Release Technology, New York, Marcel Dekker, Inc. 2000, 6: 431-465.
7. Sayed I. Abdel-Rahman, Gamal MM, El-Badry M; Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets, Saudi Pharmaceutical Journal, 2009, 17(4): 283-288.
8. Borodkin S., Encyclopedia of pharmaceutical technology (New York: Marcel Dekker Inc.), 1993, 8: 203-216.
9. Zate SU, Kothawade PI, Mahale GH, Kapse KP, Anantwar SP; Gastro retentive bioadhesive drug delivery system: A review. Int. J. Pharm. Tech. Res. 2010; 2(2): 1227- 1235.
10. Gupta S, Singh RP, Sharma R, Kalyanwat R, Lokwani P; Osmotic Pumps : Review, Pharmacie Globale (IJCP) 2011, 6(1): 212-221.
11. Ahuja AK, Khar RP and Ali J; Mucoadhesive drug delivery system, Drug Dev Ind Pharm. 1997, 23 (5): 489-515.
12. Sachan NK, Bhattacharya A; Basics and therapeutic potential of oral mucoadhesive multiparticulate drug delivery systems. Int. J. Pharm. Clin. Res. 2009, 1(1): 10-14.
13. Punitha S, Girish Y; Polymers in mucoadhesive buccal drug delivery system, Int. J. Res. Pharm. Sci. 2010, 1(2): 170-186.
14. Bhatt DA, Pethe AM. Mucoadhesive drug delivery system: An overview, J. Pharm. Res. 2010, 3(8): 1743-1747.
15. Jasti B, LI X, Cleary G; Recent advances in mucoadhesive drug delivery systems. Pharm. tech. 2003, 4: 194-196.
16. Muthukumaran M, Dhachinamoorthi D, Chandra