Volume : 08, Issue : 07, July – 2021

Title:

18.FORMULATION AND IN VITRO EVALUATION OF VILDAGLIPTIN FLOATING TABLETS

Authors :

A.V. S. Hima bindu*, G. Bhavya, Dr. K. Padmalatha

Abstract :

The main aim of the present work was to formulate and evaluate Vildagliptin floating tablets. Vildagliptin is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. The present research work was aimed to design, develop and evaluate floating tablets containing Vildagliptin for controlled release by direct compression method. Various proportions of polymer such as HPMC K 100M was used in all formulations. Optimization of formulation was done by studying effect of drug to polymer ratio on drug release. FT-IR studies indicated absence of any interaction between Vildagliptin and polymer (HPMC K 100M) and excipients. Six formulations were prepared and formulation F6 possessed good floating property with total floating time more than 12 hours. The tablets were also evaluated for its hardness, friability, buoyancy time and In-Vitro drug release test. All parameters complied with IP limits. The optimized formulation was found to be F6 which released 82.88% of drug in 12 h in vitro, while the buoyancy time was 1.16 min. The optimized formulation followed first-order kinetics and Higuchi’s model in drug release.
Key words: Floating drug delivery, Vildagliptin, HPMC K100 M, Buoyancy, Controlled release

Cite This Article:

Please cite this article in press A.V. S. Hima bindu et al., Formulation And In Vitro Evaluation Of Vildagliptin Floating Tablets.., Indo Am. J. P. Sci, 2021; 08(07).

Number of Downloads : 10

References:

1. Rohilla Ankur, Dahiya Amarjeet, Rohilla seema, Khan M.U. Gastroretentive Dosage Forms: Review on Floating Drug Delivery Systems. Int J Pharm Sci Res 2011; 2(5): 72-78.
2. Pawar V. K Kansal S, Garg G, Awasthi R, Singodia D, Kulkarni GT. Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems. AOJDD 2011; 18(2): 97–110.
3. Ashok A. Hajare , Vrushali A. Patil. Formulation and Characterization of Metformin Hydrochloride Floating Tablets. Asian J. Pharm 2012 ;2(3): 111-117.
4. Purnima Tripathi, U. Ubaidulla,Roop Kishan Khar, Vishwavibhuti. Floating Drug Delivery System. A Review. Int. J. Res. Dev. Pharm. l. Sci. 2012; 1(1): 1-10.
5. Dahiya amarjeet, Rohilla ankur, Rohilla seema, Khan M. U. Gastro retentive dosage forms : Review on floating drug delivery systems. Int. Res. J. Pharm. 2011; 2 (5): 72-78.
6. Shiv Shankar Hardeni, Ankit Jain, Ritesh Patel, Anu kaushal. Floating Drug Delivery Systems: A Review. Asian J. Pharm. Life. Sci. 2011; 1 (3): 187-192.
7. Moga Nakagawa T, Ichikondo S, Sasai Y, Kuzuya M. Preparation of floating drug system by plasma technique. Chem Pharm. Bull. 2006 ;54(4): 514-518.
8. Permender Rathee, Manish jain, Sushila Rathee, Arun Nanda, Aashima Hooda. Gastroretentive Drug Delivery Systems: A Review of Formulation Approaches. J Pharm Innov. 2012; 1(2): 95-106.
9. Mathew M. M., Joseph J., Mohan T. Review Article on Floating Drug Delivery System. Int. J. Pharm. Chem. Sci 2014; 3(3): 775-790.
10. Sarawade A., Ratnaparkhi M. P., Chaudhari S. Floating Drug Delivery System: An overview. Int. J. of Res. Dev Pharm .l.Sci 2014; 3(5): 1106 – 1115.
11. Karthik Kumar Reddy D, Kavitha K , Rupesh kumar M ,Jagadeesh singh SD, Srinivasan. A review on Floating Drug Delivery System. World J Pharm Sci 2014; 3(7): 508-522.
12. Pritesh Jha, Vipul Prajapati, Himanshu Solanki, Girish Jani, Ushma Kotak. Pharmaceutical aspects of various Floating Drug Delivery System. World J Pharm Sci 2015; 4(4): 569-589..
13. Ami M, Krunal S, Hejal P. Advancements in Controlled Release of Gastroretentive Drug Delivery System: A Review. Journal of Drug Delivery & Therapeutics 2012; 2(3): 12-21.
14. Amit Kumar Nayak, Ruma Maji, Biswarup Das. Gastroretentive drug delivery systems: A Review. Asian J Pharm Clin Res 2010 ; 3(1): 2-10.
15. Mishra Jhansee, Dash Alok Kumar. Recent Advances in Gastro Retentive Drug Delivery System: A Review. Mintage Journal of Pharmaceutical & Medical Sciences 2013; 2(2):25-27.
16. Parveen Kumar, Nirmala, S Hari Kumar. Approaches for Gastroretentive Drug Delivery Systems-A Review. Journal of Drug Delivery & Therapeutics 2014; 4(3): 14-24.
17. Singh B. N., Kim H. K. Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention. J .Cont. Rel 2000; 63: 235–259.
18. Dongare P. S., Darekar A. B. Gondkar S.B. R.B. Saudagar .Floating Drug Delivery System: A Better Approach. Intern. J. Pharm. and Bio Sci 2013; 3(4): 72-85.
19. Vedha Hari Samyuktha Rani B. Brahma Reddy.A. , Punitha. S., Parimala Devi, Victor Rajamanickam. The Recent Developments on Gastric Floating Drug Delivery Systems: An Overview. International. J. Pharm. Tech. Res 2010; 2(1): 524-534.
20. Amal H, El-kamel, Doaea H, Al-shora, Yousry M, El-sayed. Formulation and pharmacodynamic evaluation of captopril sustained release microparticles. J. Microencapsul. 2006; 23(4): 389–404.
21. Nikitha Dixit. Floating drug delivery system; Journal of c pharma research 2011;7 (1):6-20.
22. Abhishek Chandel, Kapil Chauhan, Bharat Parashar, Hitesh Kumar, Sonia Arora. Floating drug delivery systems: A better approach. International Current Pharmaceutical Journal 2012, 1(5): 110-118.
23. Subhash Desai, Sanford Bolton. A Floating Controlled-Release Drug Delivery System: In vitro-in vivo Evaluation. Pharmaceutical Research 1993:10(9): 1321–1325.
24. Uddin M, Rathi P.B, Siddiqui A.R, Sonawane A.R, Gadade D.D. Recent development in floating delivery systems for gastric retention of drugs an overview. Asian J. Bio. Pharm. Sci. 2011; 1 (3): 26-42.