Volume : 08, Issue : 06, June – 2021
Title:
18.NEW TECHNOLOGY RELATED TO DRUG DELIVERY OF MICROEMULSION FOR OCULAR DRUG DELIVERY
Authors :
Pawan Bhandari*, Ashutosh Badola
Abstract :
Delivery of drugs into eyes using conventional dosage form or conventional drugs eg.solutions is a complicated and considerable challenges to the scientist for the treatment of ocular diseases. In Ocular drug delivery system the scientist faced many challenges due to unique structure, anatomy and physiology of eye. The aim of the present study was to develop Erythromycin Microemulsion for Ocular drug delivery. Micro emulsions (ME) are thermodynamically stable and clear mixtures of oil, surfactants, and water sometimes also available in combination with co surfactants. Erythromycin belongs to the class of Macrolide antibiotics & drug delivery through microemulsion via ocular enhaned bioavailability. The main objective of the present investigation was to formulate and characterise microemulsion for ocular drug delivery. 70% of the ophthalmic preparations are conventional dosage forms, extensive pre corneal loss caused by rapid drainage and high tear liquid are the main drawbacks associated with these systems, only 1 to 5% of the total drug penetrates into cornea and reaches to the intraocular tissue, to overcome these problems, microemulsion based systems are developed. The microemulsion was prepared by using different ingredients are as follows: oleic acid as an oil phase, tween 80 as surfactant, ethanol as co surfactant and 0.5 N NAOH as aqueous phase. The optimization and formulation chart was carried out using 23 factorial design. The prepared microemulsion was evaluated by using various evaluation parameters such as PH, Particle Size and Zeta potential etc.
Keywords: Microemulsion, Conventional dosage form, Thermodynamically, Surfactant, Co-surfactant, Isotropic, Bioavailability, Amphiphile, Patent, Evaluation of Microemulsion.
Cite This Article:
Please cite this article in press Pawan Bhandari et al., New Technology Related To Drug Delivery Of Microemulsion For Ocular Drug Delivery., Indo Am. J. P. Sci, 2021; 08(06).
Number of Downloads : 10
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