Volume : 08, Issue : 03, March – 2021

05.EFFICACY OF NITAZOXANIDE AND PROBIOTICS IN CHILDREN PRESENTING WITH ACUTE WATERY DIARRHEA PRESENTING AT TERTIARY CARE HOSPITAL, KARACHI

Dr Jaweriah Ali Shaikh, Professor Muhammad Iqbal, Dr Farhana Zafar, Dr Hafsah Ali Shaikh

 

Abstract :

Objective: To compare the efficacy of nitazoxanide and probiotics in children presenting with acute watery diarrhea presenting at Tertiary Care Hospital, Karachi.
Material and Methods: The study design was randomized control trial. Study was conducted at Department of Pediatrics, Ziauddin University Hospital, Karachi. The duration of this study was Six months after approval from 02 December 2019 to 02 June 2020. Data was prospectively collected from patients after taking a verbal consent. 160 patients who met the diagnostic criteria were included. Brief history was taken and demographic information was entered in the Performa. Quantitative data was presented as simple descriptive statistics giving mean and standard deviation and qualitative variables was presented as frequency and percentages. Effect modifiers were controlled through stratification. Post stratification chi square test was applied taking p-value of ≤0.05 as significant.
Results: A total of 160 patients were included in this study. Out of 80 patients in the nitazoxanide group mean age, duration of diarrhea, length of hospital stay, height, weight and Vesikari score in our study was 24.21±4.24 months, 5.87±1.78 days, 8±2.54 days, 130.6±10.21 cm, 27.7±2.25 kg and 4.7±0.89 respectively. Whereas, out of 80 patients in the probiotics group minimum age, duration of diarrhea, length of hospital stay, height, weight and Vesikari score in our study was 26.48±4.24 months, 6.41±1.14 days, 8±1.89 days, 121.9±7.47 cm, 29.2±3.41 kg and 5.1±0.58 respectively. Efficacy in the nitazoxanide group was 67 (83.8%) compared with 58 (72.5%) in the probiotic group.
Conclusion: Treatment with nitazoxanide and probiotics is effective in the management of children with acute watery diarrhea. Small differences in favor of nitazoxanide were found in comparison with probiotics. Nitazoxanide is an important treatment option for acute watery diarrhea.
Key Words: Acute Watery Diarrhea, Nitazoxanide, Probiotics And Efficacy.

Cite This Article:

Please cite this article in press Jaweriah Ali Shaikh et a.,l Efficacy Of Nitazoxanide And Probiotics In Children Presenting With Acute Watery Diarrhea Presenting At Tertiary Care Hospital, Karachi., Indo Am. J. P. Sci, 2021; 08(03).

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