Volume : 09, Issue : 03, March – 2021
19.GREEN TEA; BEST WAY TO STRUGGLE LIPID
Mohamed Madi, Fouad Ibrahim, Ahmed G. Elsayed, Laila M. Elgendy, Elsayed A. Emara, Salima Hawda
Abstract :
Introduction: Tea is one of the most common famous drink used daily in many countries in the world. Green tea contains polyphenolic compounds as catechins, that contains epigallocatechin gallate (EGCG). The lowering of plasma cholesterol levels and blood pressure as well as improvement of insulin sensitivity and endothelial function by green tea.
Aim of the work: Study the effect of green tea on obesity, blood lipid level and its effect on fatty liver.
Materials and Methods: All animal procedures were approved by the ethical committee of Faculty of Medicine, Tanta University. Thirty male Albino rats in the range of 230–280 g body weight was used in this study. All subjects were kept in an animal room of Physiology Department of Faculty of Medicine, Tanta University, in a controlled temperature and 12:12 h light/dark cycle with free access to food and water. The animals were divided into 3 groups of 10 animals each. Group-1: the sham group (sham operated, no obesity). Group-2: the vehicle group (obesity induced rats treated with normal saline). Group-3: the ghrelin group (obesity induced rats treated with EGCG).
Results: Body weight, fat deposits, adiposity index and serum cholesterol increased significantly in a time-dependent manner in obese and control animals but were higher in the obese group (HFD > SD). High fat diet caused significant increases in the serum cholesterol level indicating high body lipid and obesity but when EGCG was administered after the beginning of high fat diet, these elevations were significantly depressed. In the vehicle group (obesity induced + saline), areas of hepatocyte necrosis in the liver parenchyma, lymphocytic infiltration, expansion of sinusoids and scattered congestion were detected. Hepatocyte damage was not observed in the liver parenchyma of the EGCG group (obesity induced + EGCG) except for scattered necrotic hepatocytes. Expansion of blood sinusoids was less compared to the vehicle group (obesity induced + saline).
Conclusion: In conclusion, since the administration of EGCG increase lipolysis and the accumulation of neutrophils in the damaged hepatic tissue, this agent appears to play a cytoprotective role in the liver insulted by fatty infiltration with obesity. It seems likely that Green tea (EGCG) is put in consideration as a potential therapeutic agent against obesity and hyperlipidemia.
Keywords: Green Tea; EGCG; Obesity; Hyperlipidemia.
Cite This Article:
Please cite this article in press Mohamed Madi et al., Green Tea; Best Way To Struggle Lipid.,Indo Am. J. P. Sci, 2021; 08(03).
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References:
2. Fatima M. and Rizvi S.I.; Anti oxidative effect of black tea theaflavin on erythrocytes subjected to oxidative stress. Natl. Acad. Sci. Lett. 2015;38, 25–28.
3. Wang Y.C. and Bachrach U.; The specific anti-cancer activity of green tea (-)-epigallocatechin-3-gallate (EGCG). Amino Acids 2002, 22, 131–143.
4. Lee W., Min W.K., Chun S., Lee Y.W., Park H., Lee D.H., Lee Y.K. and Son J.E.; Long-term effects of green tea ingestion on atherosclerotic biological markers in smokers. Clin. Biochem. 2005;38, 84–87.
5. Anandhan A., Tamilselvam K., Radhiga T., Rao S., Essa M.M. and Manivasagam T.; Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic mptp/probenecid induced Parkinson’s disease. Brain Res. 2012;1433, 104–113.
6. Chung S. Yang, Jinsong Zhang, Le Zhang, Jinbao Huang and Yijun Wang; Mechanisms of Body Weight Reduction and Metabolic Syndrome Alleviation by Tea. Mol Nutr Food Res. 2016; 60(1): 160–174.
7. Sang S., Lambert J.D., Ho C.T. and Yang C.S.; The chemistry and biotransformation of tea constituents. Pharmacol Res. 2011; 64:87–99.
8. Tao L., Forester S.C. and Lambert J.D.; The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (−)-epigallocatechin-3-gallate, in oral cells. Mol Nutr Food Res. 2014; 58:665–676.
9. Munir K.M., Chandrasekaran S., Gao F. and Quon M.J.; Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications. Am J Physiol Endocrinol Metab. 2013; 305:E679–E686.
10. Rietveld A. and Wiseman S.; Antioxidant effects of tea: evidence from human clinical trials. J Nutr 2003;133:3285S-92S.
11. Sinija V.R. and Mishra H.N.; Green tea: Health benefits. J Nutr Env Med. 2008;17(4):232-242.
12. Byun JK, Yoon BY, Jhun JY, Oh HJ, et al. Epigallocatechin-3-gallate ameliorates both obesity and autoinflammatory arthritis aggravated by obesity by altering the balance among CD4+ T-cell subsets. Immunol Lett. 2014; 157:51–59.
13. Taylor BA, Phillips SJ: Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics 1996;34(3):389-398.
14. Bose M, Lambert JD, Ju J, Reuhl KR, et al. The major green tea polyphenol, (−)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J Nutr. 2008; 138:1677–1683.
15. Henning, S.M.; Yang, J.; Hsu, M.; Lee, R.; Grojean, E.M.; Ly, A.; Li, Z. Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice. Eur. J. Nutr. 2017, 1–11.
16. Jobu, K.; Yokota, J.; Yoshioka, S.; Moriyama, H.; Murata, S.; Ohishi, M.; Miyamura, M. Effects of Goishi tea on diet-induced obesity in mice. Food Res. Int. 2013, 54, 324–329.
17. Hodgson AB, Randell RK, Boon N, Garczarek U, et al. Metabolic response to green tea extract during rest and moderate-intensity exercise. J Nutr Biochem. 2013; 24:325–334.
18. Chen YK, Cheung C, Reuhl KR, Liu AB, et al. Effects of green tea polyphenol (−)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice. J Agric Food Chem. 2011; 59:11862–11871.
19. Okuda MH, Zemdegs JC, de Santana AA, Santamarina AB, et al. Green tea extract improves high fat diet-induced hypothalamic inflammation, without affecting the serotoninergic system. J Nutr Biochem. 2014; 25:1084–1089.
20. Ortsater H, Grankvist N, Wolfram S, Kuehn N, Sjoholm A. Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. Nutr Metab (Lond). 2012; 9:11.