Volume : 09, Issue : 03, March – 2021
28.A CASE REPORT ON ATT INDUCED HEPATITIS
N. Ravali*, B. Sathiswara, R. Sidda Rama
Abstract :
Anti-TB drugs have shown that they are able to contain and kill Mycobacterium tuberculosis effectively; they are known to induce various adverse effects, including liver injury, skin reactions, gastrointestinal and neurological disorders. Anti-tuberculosis drug induced liver injury (ATLI) is one of the most important and serious adverse effects, which results in a low treatment success rate. Hepatitis adverse effect seen in tubercular suffered patient due to anti tubercular drug therapy. Case: In this case, the patient was receiving anti-tubercular drugs from 3 months and developed hepatitis which is a severe adverse drug reaction. Naranjo’s causality assessment algorithm was used to assess the adverse effect and it indicated anti-tubercular drugs as probable cause of hepatitis.
Key Words: Hepatitis, Anti-tubercular drugs, ADR Analysis, Re-Challenge and De-Challenge.
Cite This Article:
Please cite this article in press N. Ravali et al., A Case Report on Att Induced Hepatitis., Indo Am. J. P. Sci, 2021; 08(03).
Number of Downloads : 10
References:
2. Hussain Z, Kar P, Hussain SA. Antituberculosis drug-induced hepatitis: risk factors, prevention and management. Indian J Exp Biol, 2003; 41:1226-32.
3. Frieden TR, Sterling TR, Munsiff SS, Watt CJ, Dye C. Tuberculosis. Lancet, 2003; 362: 887-99.
4. Girling DJ. The hepatic toxicity of antituberculosis regimens containing isoniazid, rifampicin and pyrazinamide. Tubercle, 1978; 59:13-3.