Volume : 09, Issue : 03, March – 2021

30.MULTI DRUG RESISTANCE SEPSIS IN NEONATES AND THEIR ANTIBIOTIC SENSITIVITY

Dr Muhammad Iqbal, Dr Madiha Waseem

Abstract :

Introduction: – Neonatal sepsis remains a serious problem in any neonatal intensive care unit (NICU). Bacterial organisms have developed increased resistance to commonly used antibiotics. The aim of our study was to determine the multidrug resistance sepsis in neonates and their antibiotic sensitivity
Subject & methods: This single centre cross sectional study was conducted from the May 2020 to Nov 2020 in pediatric department, Ziauddin University Hospital, Karachi. All patients who fulfilled the inclusion criteria were included in the study. After ethical approval and informed and written consent, multiple sets of blood cultures were sent and antibiotic sensitivities were then assessed on the bacterial isolate to reach the outcome i-e frequency of multidrug resistance.
Results: – Total of 185 neonates admitted in neonatal units with sepsis were included. 72 neonates (38.9%) were males & 113 (61.1%) were females with the mean age of 13.810+7.865 days. The Multidrug resistance (MDR) was seen in 90 neonates (48.6%).
Conclusion: There is an alarming increase in frequency multidrug resistance to the commonly used antibiotics, it increases with the increase in age of neonate and predominant in female gender.
Keywords: Sepsis, Multidrug Resistance, Neonates, Antibiotic Sensitivity

Cite This Article:

Please cite this article in press Muhammad Iqbal et al., Multi Drug Resistance Sepsis In Neonates And Their Antibiotic Sensitivity., Indo Am. J. P. Sci, 2021; 08(03).

Number of Downloads : 10

References:

1. Al-Shamahy HA, Sabrah AA, Al-Robasi AB, Naser SM. Types of bacteria associated with neonatal sepsis in al-Thawra university hospital, sana’a, yemen, and their antimicrobial profile. Sultan Qaboos Uni Med J. 2012;12(1):48–54.
2. Ganatra HA, AKM Z. Neonatal infections in the developing world. Semin Perinatol. 2010;34(6):416–25
3. Lawn JE, Cousens S, Zupan J. 4 million neonatal deaths: when? where? why? Lancet. 2005;365(9462):891–90.
4. Acquah S, Quaye L, Sagoe K, Ziem J, Bromberger P, Amponsem A, et al. Susceptibility of bacterial etiological agents to commonly-used antimicrobial agents in children with sepsis at the tamale teaching hospital. BMC Infect Dis. 2013;13:89.
5. Verma P, Berwal PK, Nagaraj N, Swami S, Jivaji P, Narayan S, et al. Neonatal sepsis: epidemiology, clinical spectrum, recent antimicrobial agents and their antibiotic susceptibility pattern. Int J Contemp Padiatr. 2015;2(3):176–80.
6. Shane AL, Stoll BJ. Recent developments and current issues in the epidemiology, diagnosis, and management of bacterial and fungal neonatal sepsis. Am J Perinatol. 2013;30(2):131–41.
7. Jiang Z, Ye G. 1: 4 matched case-control study on influential factor of early onset neonatal sepsis. Eur Rev Med Pharmacol Sci. 2013 Sep;17(18):2460-6.
8. Aku FY, Akweongo P, Nyarko K, Sackey S, Wurapa F, Afari EA, et al. Bacteriological profile and antibiotic susceptibility pattern of common isolates of neonatal sepsis, ho municipality, ghana-2016. Maternal health, Neonatol Perinatol. 2018 Dec;4(1):2.
9. Aamir MM, Ali E, Hamouda M, Mourad F. Prevalence of multidrug resistant bacteria causing late-onset neonatal sepsis. Int J Curr Microbiol App Sci. 2015;4(5):172-90.
10. Awad HA, Mohamed MH, Badran NF, Mohsen M, Abd-Elrhman AS. Multidrug- resistant organisms in neonatal sepsis in two tertiary neonatal ICUs, Egypt. J Egy Public Health Associ. 2016 Mar 1;91(1):31-8.
11. Mohsen L, Ramy N, Saied D, Akmal D, Salama N, Haleim MM, Aly H. Emerging antimicrobial resistance in early and late-onset neonatal sepsis. Antimic Resist Inf Cont. 2017 Dec;6(1):63.
12. Darmstadt GL. Global newborn health challenges and opportunities. Proceedings of 10th National Annual Pediatric Conference. 2001;22.
13. Yurdakok M. Antibiotic use in neonatal sepsis. Turk J Pediatr. 1998;40:17–33.
14. Rahman S, Hameed A, Roghani MT, Ullah Z. Multidrug resistant neonatal sepsis in Peshawar, Pakistan. Archives of Disease in Childhood-Fetal and Neonatal Edition. 2002 Jul 1;87(1):F52-4.
15. Maryam W, Laeeq A, Maqbool S. Neonatal sepsis spectrum of antibiotic resistance. Proceedings of 10th Annual National Pediatric Conference. 2001;57
16. Bhutta ZA, Yusuf K. Neonatal sepsis in Karachi: factors determining outcome and mortality. J Trop Pediatr1997;43:65–70.
17. Joshi SJ, Ghole VS, Niphadkar KB. Neonatal gram negative bacteremia. Indian J Pediatr2000;67:27–32.
18. Orrett FA, Shurland SM. Neonatal sepsis and mortality in a regional hospital in Trinidad: aetiology and risk factors. Ann Trop Paediatr2001;21:20–5.
19. Greenberg D, Shinwell ES, Yagupsky P, et al. A prospective study of neonatal sepsis and meningitis in southern Israel. Pediatr Infect Dis J1997;16:768–73.
20. Awad HA, Mohamed MH, Badran NF, Mohsen M, Abd-Elrhman AS. Multidrug-resistant organisms in neonatal sepsis in two tertiary neonatal ICUs, Egypt. J Egy Public Health Associ. 2016 Mar 1;91(1):31-8.
21. Acquah S, Quaye L, Sagoe K, Ziem J, Bromberger P, Amponsem A, et al. Susceptibility of bacterial etiological agents to commonly-used antimicrobial agents in children with sepsis at the tamale teaching hospital. BMC Infect Dis. 2013;13:89.
22. Aku FY, Akweongo P, Nyarko K, Sackey S, Wurapa F, Afari EA, et al. Bacteriological profile and antibiotic susceptibility pattern of common isolates of neonatal sepsis, ho municipality, ghana-2016. Maternal health, Neonatol Perinatol. 2018 Dec;4(1):2.
23. Mohsen L, Ramy N, Saied D, Akmal D, Salama N, Haleim MM, Aly H. Emerging antimicrobial resistance in early and late-onset neonatal sepsis. Antimic Resist Inf Cont. 2017 Dec;6(1):63.
24. Anwer SK, Mustafa S, Pariyani S, Ashraf S, Taufiq KM. Neonatal sepsis: an etiological study. JOURNAL-PAKISTAN MEDICAL ASSOCIATION. 2000 Mar 1;50(3):91-3.
25. Kaushik SL, Parmar VR, Grover N, Grover PS, Kaushik R. Neonatal sepsis in hospital born babies. The Journal of communicable diseases. 1998 Sep 1;30(3):147-52.
26. Joshi SG, Ghole VS, Niphadkar KB. Neonatal gram-negative bacteremia. The Indian Journal of Pediatrics. 2000 Jan;67(1):27-32.
27. Pennington H. Millenium bugs. Biologist (London). 2000; 47:93–5
28. Rahman S, Hameed A, Roghani MT, Ullah Z. Multidrug resistant neonatal sepsis in Peshawar, Pakistan. Archives of Disease in Childhood-Fetal and Neonatal Edition. 2002 Jul 1;87(1):F52-4.
29. Levy SB. Antibiotic and antiseptic resistance: impact on public health. The Pediatric infectious disease journal. 2000 Oct 1;19(10): S120-2.