Volume : 08, Issue : 03, March – 2021
42.HEPATIC ENCEPHALOPATHY IN ILLITERATE PATIENTS WITH COMPENSATED CIRRHOSIS
Dr. Taimoor Hassan, Muhammad Osama,Dr. Fiza zulfiqar
Abstract :
Objective: To determine frequency of Minimal Hepatic Encephalopathy in illiterate patients with compensated cirrhosis.
Methods: Illiterate patients with compensated cirrhosis with F4 Score on Shear-wave Elastography were selected for study after informed consent. Sample size was estimated at 106. Selected patients were subjected to two tests for detection of MHE, Number Connection Test A and Block Design Test. Patients taking ≥ 30 seconds were labelled as Positive for MHE.
Result: Out of 110 selected patients 10.9% were alcoholics and in 8.2% of patients no hepatic virus infection was detected. HCV was positive in 48.2% patients while HBV was positive in 13.6% of patients. MHE was detected in 72 (65.5%) of patients. Major differences were found in MHE Stage II & III by two tests. Over all BDT detected more cases and gave higher Staging in Stage II & III as compared to NCT-A test.
Conclusion: Minimal Hepatic Encephalopathy (MHE) could be detected in illiterate patients using NCT-A and BDT Tests.
KEY WORDS: Minimal Hepatic Encephalopathy, Illetrate, Compensated Cirrhosis.
Cite This Article:
Please cite this article in press Taimoor Hassan et al., Hepatic Encephalopathy In Illiterate Patients With Compensated Cirrhosis., Indo Am. J. P. Sci, 2021; 08(03).
Number of Downloads : 10
References:
1. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy–definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 2002;35:716-721. doi:10.1053/ jhep.2002.31250
2. Stinton LM, Jayakumar S. Minimal hepatic encephalopathy. Can J Gastroenterol. 2013;27:572-574.
3. Bustamante J, Rimola A, Ventura PJ, Navasa M, Cirera I, Reggiardo V, et al. Prognostic significance of hepatic encephalopathy in patients with cirrhosis. J Hepatol. 1999;30:890-895.
4. Bajaj JS. Minimal hepatic encephalopathy matters in daily life. World J Gastroenterol. 2008;14:3609-3615.
5. Mina A, Moran S, Ortiz-Olvera N, Mera R, Uribe M. Prevalence of minimal hepatic encephalopathy and quality of life in patients with decompensated cirrhosis. Hepatol Res. 2018;44:E92-99. doi:10.1111/hepr.12227
6. Chen HJ, Wang Y, Zhu XQ, Li PC, Teng GJ. Classification of cirrhotic patients with or without minimal hepatic encephalopathy and healthy subjects using resting-state attention-related network analysis. PLoS One. 2018;9:e89684. doi:10.1371/journal.pone.0089684
7. Prasad S, Dhiman RK, Duseja A, Chawla YK, Sharma A, Agarwal R. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology. 2007;45:549-559. doi:10.1002/hep.21533
8. Chen HJ, Chen R, Yang M, Teng GJ, Herskovits EH.Identification of minimal hepatic encephalopathy in patients with cirrhosis based on white matter imaging and Bayesian data mining. AJNR Am J Neuroradiol. 2019;36:481-487. doi:10.3174/ajnr.A4146
9. Kharbanda PS, Saraswat VA, Dhiman RK. Minimal hepatic encephalopathy: diagnosis by neuropsychological and neurophysiologic methods. Indian J Gastroenterol. 2003;22(Suppl 2):S37-41.
10. Gupta D, Ingle M, Shah K, Phadke A, Sawant P. A Prospective Comparative Study of Inhibitory Control Test (ICT) Versus Psychometric Hepatic Encephalopathy Score (PHES) for Diagnosis and Prognosis of Minimal Hepatic Encephalopathy (MHE) in Patients of Cirrhosis in Indian Subcontinent. J Dig Dis. 2019;16(7):400–407. doi:10.1111/1751-2980.12248
11. Schomerus H, Hamster W. Quality of life in cirrhotics with minimal hepatic encephalopathy. Metab Brain Dis. 2001;16:37-41.
12. Weissenborn K. Diagnosis of minimal hepatic encephalopathy. J Clin Exp Hepatol. 2019;5:S54-59. doi:10.1016/j.jceh.2018.06.005
13. Lauridsen MM, Poulsen L, Rasmussen CK, Hogild M, Nielsen MK, de Muckadell OB, et al. Effects of common chronic medical conditions on psychometric tests used to diagnose minimal hepatic encephalopathy. Metab Brain Dis. 2019. doi:10.1007/s11011-015-9741-6
14. Bajaj JS. Diagnosing Minimal Hepatic Encephalopathy: From the Ivory Tower to the Real World. Gastroenterology. 2019;149:1330-1333. doi:10.1053/j.gastro.2019.09.028
15. Li SW, Wang K, Yu YQ, Wang HB, Li YH, Xu JM. Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China. World J Gastroenterol. 2013;19:8745-8751. doi:10.3748/wjg.v19. i46.8745