Volume : 08, Issue : 11, November – 2021



Authors :

S. Ahmed ullah Hussaini, Saher Shah Khan, Amina Begum, Juveria Fatima and Nausheen Noor

Aim & objectives: The principle aim was to study Drug utilization and Evaluation of Anti-Hypertensive Drugs and it’s Adherence to standard treatment guidelines and importance of BP control; hypertension is persistent elevation of arterial blood pressure.
Methodology: A Prospective and observational study was carried out on 100 subjetcs in the Department of general medicine in Osmania General Hospital, a tertiary care teaching hospital for a period of 6 months.
Results: The data collected was analyzed a presented using simple statistics and and presented in counts or percentage. Out of 100 subjects (64 %) were males and (36%) were females. Maximum number of the patients were found in age group>61 with (52%) people in it.There were 70 patients with different comorbid condition among which Diabetes (25%) was the highly prevaled comorbid condition. Monotherapy (59%) was oftenly prescribed in both comorbi and non-comorbid diseased conditions of the study. Diuretics (Furosemide) Calcium Channel Blocker (Amlodepine), Angiotensin Renin Blocker (Telmisartan), Angiotensin converting enzyme (Enalapril), Beta blocker(metaprolol) were frequently prescribed Anti-hypertensive class of drugs prescribed in monotherapy. The presence of comorbidities makes the situation more complicated in such conditions Dualtherapy (27%), Triple therapy (14%) was used. Among dual combination (27%) Diuretics and Angiotnesin renin blocker was primarily selected antihypertensive class. The triple combination therapy (14 %) was rarely prescribed in extreme conditions the class of drug used in triple combination was calcium channel blocker, Diuetic, centrally sympathomimetics. In the study most of the patients were alcoholics (39%), smokers (30%). Participant’s adherence status: Prevalance rate on self-care activity among hypertensive patients was conducted there were 67% subjects with hypertension of >2 years,72%patients were taking medications only 44%patients knows about medication, medication adherence was observed in 67% patients, adherence to rationality of prescription was 83%, non-adherence to low salt diet was high with 56% outcome as complication was observed in 75% patients.
Keywords: Hypertension, Diabetes, comorbidities, monotherapy, combination drug therapy and Diuretics.

Cite This Article:

Please cite this article in press Juveria Fatima et al, A Prospective Observational Study On Drug Utilization And Evaluation Of Anti-Hypertensive Drugs And It’s Adherence To Standard Treatment Guidelines In Tertiary Care Hospital, Indo Am. J. P. Sci, 2021; 08(11).

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1. Abegaz T.M., Ousman A. Abdela, Akshaya S. Bhagavathula, and Fitsum S. Teni. ”Magnitude and determinants of uncontrolled blood pressure among hypertensive patients in Ethiopia: hospital based observational study” 2018.
2. Andreadis EA, Tsourous GI, Marakomichelakis GE et al. High-dose monotherapy vs low-dose combination therapy of calcium channel blockers and angiotensin receptor blockers in mild to moderate hypertension. J. Hum. Hypertens; Anchala R, Hypertension in India
3. Brian S., MD, FRCPC “Stroke Prevention” Medscape2019.
4. Birgit J. T., “Hypertension and its association with socioeconomic factors in rural Nepal” 2017
5. Black HR. Triple fixed-dose combination therapy: back to the past. Hypertension 54(1), 19–22 (2009).
6. Borghi C. Lercanidipine in hypertension. Vasc. Health Risk Manag.), (2005).
7. Dutta S. Utilization Study of Antihypertensives in a South Indian Tertiary Care Teaching Hospital and Adherence to Standard Treatment Guidelines. J Basic Clin Pharm. 2016;8(1):33-37 DOI:10.4103/0976105.195100; https//pubmedncbi.nlm.nih.gov/28104972.
8. Epstein BJ. Improving blood pressure control rates by optimizing combination antihypertensive therapy. Expert Opin. Pharmacother. 11(12), 2011–2026 (2010). n n Presents an algorithm for the suitability of mono, dual or multiple therapy. Reviews the value of single-pill combinations and particular drug classes in various clinical settings.
9. Flack JM, Sica DA, Bakris G et al. Management of high blood pressure in blacks: an update of the International Society on Hypertension in Blacks consensus statement. Hypertension
10. Hameed MA,Dasgupta I Medication Adherence and treatment –resistant hypertension: A review Drugs context.2019;8:212560.Published 2019 Feb 4.DOI:10,7573/dic.212560: https//pubmed.ncbi.nlm.nih.gov/30774692
11. K.Vashishta study on drug utilization Pattern of Anti Hypertensive medication in tertiary care hospital of Telangana ,India DOI: http//dx.doi.org/10.18203/23192003.ijbcp20183487.
12. Kazim Hussain,Rais A Ansari,and Leon Ferder World J Cardiol.2014 May 26:245-252.Published online 2014 May 26.doi:10.4330/wjc.v6.i5.245 PMCID:PMC4038773 , PMID:24891935.
13. Kikipa Kretzer-”Evidence based prescribing pattern for hypertension among insured patients in Hawaii(2005)
14. Lau,DH; Nattel Kalman, JM; Sanders-“Modifiable Risk Factors and Atrial Fibrillation”. Circulation (Review).2017.136 (6):583–96,Lana B.-“How are diabetes and hypertension linked?”2017. Reviewed by university of Illinois-Chicago, school of medicine. Medical News Today –Newsletter.
15. Neutel JM. The role of combination therapy in the management of hypertension. Nephrol. Dial. Transplant. 21(6), 1469–1473 (2006).
16. Oladele VA, Parimalaranie Y, Benjamin L-Mbenza, Daniel Ter Goon – “Uncontrolled hypertension and its determinants in patients with concomitant type 2 diabetes mellitus in rural South Africa”2016.
17. Roger Walker Cate Whittlesea; Clinical pharmacy and therapeutics Edinburgh ; New York : Churchill Livingstone,2007.
18. Radhika, A..(2018).Drug utilization study of antihypertensive drugs in a tertiary care hospital,International journal of basic and clinical pharmacology.10.18203/2319-2003.ijbcp 20184680.
19. Ramanath KV, Venkappa KR. Study the impact of clinical pharmacist provided patientcounseling on hypertension management in rural Indian population. Arch Pharma Pract 2013;4: 28-34.
20. Rachana Anuradha HV, Shivamurthy MC. Anti hypertensive prescribing patterns and cost analysis for primary hypertension: A retrospective study. J Clin Diagn Res. 2014;8:19–22.PMC free article ,PubMed ,Google scholar.
21. S.N.Arya -”Hypertension in diabetic patients-emerging trends”. JIACM 2003;4(2)96-102
22. Spence JD. Physiologic tailoring of treatment in resistant hypertension.
23. Singh D, Katiyar P, Sawlani KK, Chaudhary SC, Nath R, Fatima SS, Kumar A and Dixit RK: Drug utilization study of antihypertensive treatment being prescribed in patients coming to medicine OPD of a tertiary care hospital in northern India. Int J Pharm Sci & Res 2020; 11(3): 1410-16. doi: 10.13040/IJPSR.0975-8232.11(3).
24. Tesfaye B Haile D, Lake B, Belachew T, Tesfaye T, Abera “Uncontrolled hypertension and associated factors among adult hypertensive patients on follow up at Jimma university teaching and specialized hospital: cross- sectional study 2017”.
25. Virdis A, Giannarelli C, Neves MF, Taddei S, Ghiadoni L. Cigarette smoking and hypertension .curr Pharm Des 2010;16(23):2518-2525 doi:10.2174/138161210792062920
26. Varakantham V, Kurakula Sailoo AK, Bharatraj DK. Antihypertensive Prescription Pattern and Compliance to JNC 7 and JNC 8 at Tertiary Care Government Hospital, Hyderabad, India: A Cross-sectional Retrospective Study. Hosp Pharm. 2018 Apr;53(2):107-112. doi: 10.1177/0018578717738080. Epub 2017 Nov 1. PMID: 29581605; PMCID: PMC5863878.
27. NICE Hypertension; The clinical management of of primary hypertension in adults.Clinical Guideline:Methods,Evidence and recommendations.
28. Wells, Barbara ;Dipirio,Joseph ;Schwinghammer ,Terry and Dipirio,Cecily ,Pharmacotherapy Handbook 9/E. New York: McGraw-Hill Education, 2014.
29. White WB, Littlejohn TW, Majul CR et al. Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1–2 hypertension. Blood Press. Monit. 15(4), 205–212 (2010). 459–466(2011).
30. Zahra Eslampanah Drug Utilisation and Evaluation study https//ijpsr.com/bft-article/ Drug utilization evaluation in a medical care hospital.