Volume : 08, Issue : 11, November – 2021
Title:
28.FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF CLONAZEPAM USING NATURAL AND SYNTHETIC SUPER DISINTEGRANTS
Authors :
Abdul Sayeed, Dr.Pawan Kumar, Dr. Syed Areefulla Hussainy
Abstract :
In this work, natural and synthetic super disintegrants were used to produce mouth dissolving tablets for anticonvulsant drugs utilizing the direct compression method. Plantago ovate mucilage (2-8%) was employed as a natural super disintegrant, while Cross carmellose sodium (2-8%) was used as a synthetic super disintegrant in the direct compression method. Extracting the drug with 0.1 N HCl and pH 6.8 phosphate buffer and measuring the absorbance at 254nm was used to estimate the anticonvulsant drug in the produced tablet formulations.
After that, post-compression parameters were tested on the prepared formulations.
In vitro drug release pattern (0.1 N HCl and pH 6.8 phosphate buffer), stability study (at 40°C/75% RH for 6 months), drug-excipient interaction (IR spectroscopy), and in vitro dispersion time were all compared to formulations including natural super disintigrant.
The overall best formulation formulations were those that contained 8% w/w natural super disintegrant Plantago ovate mucilage (FM8).
Short-term stability analysis of potential formulations revealed that drug content and In vitro dispersion time did not change significantly. There are no drug-excipient interactions, according to IR spectroscopic tests. Natural super disintegrants were found to be superior in compression to synthetic super disintegrantes with enhanced dissolving in the current study.
Keywords: Clonazepam, Plantago ovata mucilage, Cross carmellose sodium.
Cite This Article:
Please cite this article in press Abdul Sayeed et al, Formulation And Evaluation Of Mouth Dissolving Tablets Of Clonazepam Using Natural And Synthetic Super Disintegrants., Indo Am. J. P. Sci, 2021; 08(11).
Number of Downloads : 10
References:
1. Lindgreen S, Janzon L. Dysphagia: Prevalence of swallowing complaints and clinical findings. Med. Clin. North Am, 77 (1993) 3-5.
2. Kaushik D, Dureja H. Mouth dissolving tablets: A review. Indian Drugs, 41(4) (2004) 187-93.
3. Wilson CG, Washington N, Murry GR. The behavior of a fast dissolving dosage form (expidet) followed by g- scintigraphy. Int J Pharm, 40 (1987) 119-23.
4. Pankaj K, Parminder K. In vitro and In vivo characterization of mouth dissolving tablet: An updated review. J Drug Delivery and Therapeutics, 3(3) (2013) 153-157.
5. Whistler RL. Industrial gums, 2nd Ed, Academic Press, London. pp 1996.
6. Kakrani HK, Jain NK. A study on binding properties of Guggal gum. Indian J of Hospital Pharm, 18(3) (1981) 100-102.
7. Santanu C,Madhusmruti K.Comperative study of effect of natural and synthetic superdisintegrants in formulation of fast dissolve tablets. Int J Green Pharm, 2(1) (2008) 22-25.
8. Baveja SK, Gupta BM. Rheology of aqueous dispersion of plantago ovate seed husk II. Indian J Pharm Sci, 30(1) (1968) 244-51.
9. Rang HP, Dale MM, Moore PK. Pharmacology, London, Churchill livingstone, 5th Ed; 2003.
10. Malla VC, Mani Kumari M, Mariyadas U, Sushma M, Mounika N. Formulation and Evaluation of Ibuprofen Tablets by using different superdisintegrating agents. World J Pharm Pharm Sci 2016;5(5):875-883.
11. Dali shukla, Subhashis Chakraborty, Sanjay Singh, Brahmeshwarn Mishra.Mouth dissolving tablets : an overview of formulation technology.2009, 77:309- 326.
12. Tapan kumar, Dulal Krishna, Rana.Formulation aspects in the development of Orodispersible tablets: an overview. International journal of pharmacy and Pharmaceutical sciences, 2010: May 07:2(3).
13. Tejvir, Bhavandeep , Sandeep ,Gupta GD. Mouth dissolving tablets; A novel approach to drug delivery. International journal of current pharmaceutical research.2011:July 17:3(1).
14. Pagar R, Ahirrao S, Yallatikar T, Wagh M. Rev on orodispersible tablets. Int J Res Dev Pharm L Sci 2014;3:949-58.
15. Mishra S, Prajapati K, Bhardwaj P. A rev on formulation and evaluation for mouth dissolving tablet. World J Pharm PharmSci 2014;8:1778-810.
16. Kuchekar S, Badha C, Mahajan S. Mouth dissolving tablets. A novel drug del system. Pharm times 2003; 35:7-9.
17. Kumaran K, Sreekanth J, Palanisamy S. Formulation, development and evaluation of Levodopa-Carbidopa orally disintegration tablets. J Chem Pharm Res 2011; 3(3):169-175.
18. Belet H, Derle V. Analysis of patents pertaining to superdisintegrants used in tablet manufacturing. J intellectual Property Rights 2008;13:601-604.
19. Omidian H, Park K. Swelling agents and devices in oral drug delivery. J Drug Del Sci Tech 2008; 18(2):83-93.
20. Bhardwaj S, Jain V, Sharma S, Jat RC, Jain S. Orally disintegrating tablets. A rev Drug Invention Today 2010;2(1):81-88.