Volume : 08, Issue : 11, November – 2021

Title:

34.A STUDY OF VARIATIONS IN PRESENTATION OF COUGH IN POPULATION OF ISLAMABAD

Authors :

Dr. Syed Saad Ali Chishti, Dr. Ameeq Noonari, Dr. Rimsa Tahir

Abstract :

Background and Objective: Data about causes of chronic cough are lacking in our part of world. The aim of our study was to look for spectrum of causes in our setup and to determine a correlation between causes of cough and baseline factors of age, gender, and BMI and compare it to other populations.
Methods: Total 236 chronic cough patients who attended chest clinic at DHQ Teaching Hospital, Islamabad from January 2018 to June 2019 were included in this cross-sectional study. Chronic cough was defined as cough greater than eight weeks. Main causes of chronic cough taken were cough variant asthma, allergic rhinitis, interstitial lung disease, Gastro-esophageal reflux disease, bronchial hyper-reactivity, ACE-I induced cough and others’. Other demographic and clinical data were also recorded.
Results: The mean age was 45.16± 16.50 years and BMI was 26.23 ± 4.68kg/m2. Major cause of chronic cough was cough variant asthma in 111(47%). Age had significant positive correlations with ILD, ACE-I induced cough and CCF, while significant negative correlations with CVA and AR. On gender correlation, ILD and ACE-I cough were significantly found more in females. BMI had significant correlation with ACE-I cough only.
Conclusion: Variability of epidemiology of cough variant asthma, allergic rhinitis and ACE-I induced cough is comparable to worldwide data while differences exist with epidemiology of interstitial lung disease. Further research is needed in the field to delineate the local trends in this regard and compare to other population groups.

Cite This Article:

Please cite this article in press Syed Saad Ali Chishti et al, A Study Of Variations In Presentation Of Cough In Population Of Islamabad., Indo Am. J. P. Sci, 2021; 08(11).

Number of Downloads : 10

References:

1. Mahashur A. Chronic dry cough: Diagnostic and management approaches. Lung India. 2015;32(1):44-49. doi: 10.4103/0970-2113.148450
2. Smith JA, Woodcock A. Chronic Cough. N Engl J Med. 2016;375:1544-1551. doi: 10.1056/NEJMcp1414215
3. Malhotra J, Malvezzi M, Negri E, Vecchia CL, Boffetta P. Risk factors for lung cancer worldwide. Eur Respir J. 2016;48:889-902. doi: 10.1183/13993003.00359-2016
4. Mahesh PA, Jayaraj BS, Prabhakar AK, Chaya SK, Vijayasimha R. Prevalence of chronic cough, chronic phlegm & associated factors in Mysore, Karnataka, India. Indian J Med Res. 2011;134(1):91-100.
5. Sun YQ, Burgess S, Staley JR, Wood AM, Bell S, Kaptoge SK, et al. Body mass index and all-cause mortality in HUNT and UK Biobank studies: Linear and non-linear mendelian randomisation analyses. BMJ. 2019;364:l1042. doi: 10.1136/ bmj.l1042
6. Sutherland RE. Obesity and Asthma. Immunol Allergy Clin North Am. 2008;28(3):589-602. doi: 10.1016/j. iac.2008.03.003
7. Zein JG, Erzurum SC. Asthma is Different in Women. Curr Allergy Asthma Rep. 2015;15(6):28. doi: 10.1007/s11882-015-0528-y
8. Cazzoletti L, Ferrari M, Olivieri M, Verlato G, Antonicelli L, Bono R, et al. The gender, age and risk factor distribution differs in self-reported allergic and non-allergic rhinitis: a cross-sectional population-based study. Allergy Asthma Clin Immunol. 2015;11(36):1-9. doi: 10.1186/s13223-015-0101-1
9. Sheikh J, Jean T. Allergic Rhinitis: Practice Essentials, Background, Pathophysiology [Internet]. Emedicine. medscape.com. 2018 [Cited 08 September 2019]. Available from: http://emedicine.medscape.com/article/134825overview#a6
10. Vatankhah V, Khazraei H, Iranpoor H, Lotfizadeh M. Impact of high body mass index on allergic rhinitis patients. Elsevier. 2017;57(5):370-374. doi: 10.1016/j. reval.2017.05.001
11. Han YY, Forno E, Gogna M, Celedon JC. Obesity and rhinitis in a nationwide study of children and adults in the United States. J Allergy Clin Immunol. 2016;137(5):1460-1465. doi: 10.1016/j.jaci.2015.12.1307
12. Summerhill EM. Interstitial (Nonidiopathic) Pulmonary Fibrosis: Background, Pathophysiology, Epidemiology [Internet]. Emedicine.medscape.com. 2018 [Cited 08 September 2019]. Available from: http://emedicine.medscape.com/article/301337-overview#a6
13. ILDPAK Registry. Available at http://www.ildpak.com. Accessed: Sep 08, 2019.
14. Patti MG. Gastroesophageal Reflux Disease: Practice Essentials, Pathophysiology, Etiology [Internet]. Emedicine.medscape.com. 2019 [Cited 08 September 2019]. Available from: http://emedicine.medscape.com/ article/176595-overview#a6
15. Patti MG. How does obesity contribute to gastroesophageal reflux disease (GERD)? [Internet]. Emedicine.medscape. com. 2019 [Cited 08 September 2019]. Available from: https://www.medscape.com/answers/176595-45383/ how-does-obesity-contribute-to-gastroesophageal-refluxdisease-gerd
16. Mathur S. Allergy and Asthma in the Elderly. Semin Respir Crit Care Med. 2010;31(5):587-595. doi: 10.1055/s-0030-1265899
17. Ciprandi G, Pistorio A, Tosca M, Ferraro M, Cirillo I. Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma. Respir Med. 2009;103(2):289-295. doi: 10.1016/j.rmed.2008.08.008
18. Hallberg P, Persson M, Axelsson T, Cavalli M, Norling P, Johansson HE, et al. Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: A genome-wide association study in a Swedish population. Pharmacogenomics. 2017;18(3):201-213. doi: 10.2217/pgs-2016-0184
19. Shah N, Siddiqui S. An overview of smoking practices in Pakistan. Pak J Med Sci. 2015;31(2):467-470. doi: 10.12669/ pjms.312.6816
20. Villanueva PD, Alfonso F. Heart failure in the elderly. J Geriatr Cardiol. 2016;13(2):115-117. doi: 10.11909/j. issn.1671-5411.2016.02.009