Volume : 08, Issue : 10, October – 2021
Title:
28.PHYTOCHEMICAL EVALUATION & PHARMACOLOGICAL SCREENING OF ANTIDIABETIC ACTIVITY USING ETHANOLIC EXTRACTS OF PULICARIA DYSENTERICA & BROSIMUM ALICASTRUM ON EXPERIMENTAL ANIMALS
Authors :
Dr. Mehnoor Farheen***, Masrath begum**, Hadiya sultana*, Farheen Begum*
Abstract :
This project is focused on the study of anti-diabetic effects of the leaf extract of Pulicaria dysentrica &brosimum alicastrum on streptozotocin induced male Wister rats. To evaluate the anti-diabetic activity of ethanolic extract of pulicaria dysentrica & brosimum alicastrum, this is tested by phytochemical analysis, GCMS analysis, In vivo & Invitro screening models. Oral dosing of plants extracts in different doses alleviates rats blood serum levels. This may be achieved by estimating the BGL, SGOT, SGPT, TGR, TCL, ALP, HDL, VLDL, LDL and the histopathological study of the pancreas. The rats’ pancreas was dissected out from one animal of each group for histopathology examination for evaluation of hyperplasia, islets damage, and restoration of size of organ. The pancreas microscopy of toxic, standard &toxic group is compared. It was found that with the plant extract the hyperplasia is repairing when compared to toxic but is less compared to standard control. The study asserts that further research needs to be undertaken on the benefits of pulicaria dysentrica and brosimum alicastrum in diabetes. Keywords: anti-diabetes, ethanol, streptozotocin, pulicaria dysentrica, brosimum alicastrum, hyperplasia.
Cite This Article:
.Please cite this article in press Mehnoor Farheen et al, Phytochemical Evaluation & Pharmacological Screening Of Antidiabetic Activity Using Ethanolic Extracts Of Pulicaria Dysenterica & Brosimum Alicastrum On Experimental Animals., Indo Am. J. P. Sci, 2021; 08(10).
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References:
1. Pal SK, Shukla Y.etal Herbal medicine: current status and the future. Asian pacific journal of cancer prevention. 2003 Aug 20; 4(4):281-8.
2. Zahid etal introduction and importance of herbal medicine 20 may 2016
3. Tripathi KD. Essentials of Medical Pharmacology’, 5th Edition, Jaypee Brothers Medical Publications (P) Ltd., New Delhi, 2003.p. 167-84.
4. Antioxidant: Written by Atilt Arnarson BSc, PhD — Updated on July 29, 2019
5.Dragsted LO, Pedersen A, Hermetter A, Basu S, Hansen M, Haren GR, Kall M, Breinholt V, Castenmiller JJ, Stagsted J, Jakobsen J, Skibsted L, Rasmussen SE, Loft S, Sandstorm B. The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. AmJClinNutr. 2004 Jun; 79(6):1060-72. Doe: 10.1093/ajcn/79.6.1060. PMID: 15159237.
6. Written by Adda Bjarnadottir, MS, RDN (Ice) on May 21, 2019 7. Written by Ryan Raman, MS, RD on March 12, 2018
8. Medically reviewed by Natalie Olsen, R.D., L.D., ACSM EP-C — Written by Megan ware on May 29, 2018
9.Amorati R, Ferroni F, Luccarini M, Pedulli GF, Valgimigli L. 2002b. Modeling the co-antioxidant behavior of nonfunctional phenols. Application to some relevant compounds. J Org Chem 68:9654–8.
10. Aruoma OI. 1998. Free radicals, oxidative stress, and antioxidants in human health and disease. J Am Oil Chem. Soc 75:199–212.
11. Evans J. L. Gold fine I. D. Maddux B. A. Grodsky G. M. 2002Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.