Volume : 08, Issue : 10, October – 2021
Title:
43.FORMULATION AND EVALUATION OF ANTI-DIABETIC ACTIVITY OF Indigofera mysorensis NANOPARTICLES
Authors :
Ranadheer Reddy, Bhaskar Vallamkonda and K Purnachander
Abstract :
Indigofera mysorensis is one of the most traditionally using hypoglycemic agents among tribes in India and it is not Scientifically validated. Based on the above mentioned reasons, one new research is required to develop one new drug with more anti diabetic activity The main aim is Formulation and evaluation of Indigofera mysorensis. Nanoparticles, To study the anti diabetic activity of developed activity. The body weight was decreased in alloxan diabetic rats. Administration of Ethanolic extract of Indigofera mysorensis and nano particles of Indigofera mysorensis at a dose of 200 and 50mg/kg increases the body weight in alloxan induced diabetic rats. The ability of Ethanolic extract of Indigofera mysorensis and nano particles of Indigofera mysorensis at a dose of 200 and (50mg/kg) to protect massive body weight loss seems to be due to its ability to reduce hyperglycemia. From the results of the present experiments it may be concluded that formulation F3 showing formulation of Nanoparticle size, high percentage of entrapment and desired sustained release of Nanoparticle. Hence F3 formulation was optimized one. The optimized formulation F3 was found to follow zero order release pattern which was revealed by the linearity shown from the plot of time versus concentration. Nanoparticle formation were stable for 4 weeks at 40C and affirm the drug leakage – increased the higher temperature. Comparative study of Nanoparticle formulation with the marketed. The Nanoparticle formulation revealed that anti diabetic activity was released from the Nanoparticle formulation in a sustained manner for 24 Hours.
Keywords: Formulation, Evaluation, Anti Diabetic Activity, Indigofera Mysorensis Nanoparticles
Cite This Article:
Please cite this article in press Ranadheer Reddy et al, Formulation And Evaluation Of Anti-Diabetic Activity Of Indigofera Mysorensis Nanoparticles., Indo Am. J. P. Sci, 2021; 08(10).
Number of Downloads : 10
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