Volume : 08, Issue : 09, September – 2021
Title:
31.FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF FLUCONAZOLE BY SOLVENT CASTING TECHNIQUE
Authors :
P. M. M. Naga Lakshmi Varma*, Shaik Shaheda Begum, Dr. K. Padmalatha
Abstract :
The present investigation was undertaken with the objective of formulating mouth dissolving film(s) of an antifungal drug fluconazole to enhance the convenience and compliance by the elderly and pediatric patients and also to avoid first-pass metabolism. The present study was aimed to formulate and evaluate fast dissolving oral films of fluconazole using HPMC E-5, HPMC E-15, HPMC E-50, PEG 400 and sodium starch glycolate. The suitable plasticizer and its concentration were selected on the basis of flexibility, tensile strength and stickiness of the film. The films are prepared by solvent casting method and characterized by UV, FTIR studies. The formulated films gave satisfactory result for various physic-chemical evaluations such as physical appearance, weight uniformity, thickness, folding endurance, drug content, surface pH, in vitro disintegration time and in vitro drug release. Formulation F1 was considered optimum which contained drug: HPMC E5 (1:3) and sodium starch glycolate (40 mg). The study revealed that the fast disintegrating and dissolving oral thin film can be competently formulated for Fluconazole by HPMC E5 as film forming polymer by employing solvent casting technique.
KEYWORDS: Fluconazole; HPMC E5; fast dissolving oral films; Solvent casting method; In vitro dissolution.
Cite This Article:
Please cite this article in press P. M. M. Naga Lakshmi Varma et al, Formulation And Evaluation Of Fast Dissolving Oral Films Of Fluconazole By Solvent Casting Technique.,Indo Am. J. P. Sci, 2021; 08(9).
Number of Downloads : 10
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