Volume : 08, Issue : 09, September – 2021
Title:
37.SYNTHESIS AND CHARACTERIZATION OF N-METHYL INDOLE DERIVATIVES VIA DESULFITATIVE DISPLACEMENT BY VARIOUS ANILINE DERIVATIVES
Authors :
NAGALATHA, SRIDHER VANGA
Abstract :
The present work indicates a facile and efficient synthesis of some new 3- ((Substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio) acrylonitrile derivatives bearing indole moiety via desulfitative displacement by various amines. The synthetic route is well designed in such a way that reaction required minimum time for completion with catalyst-free reaction, and easy workup and purification process. The range of yield is moderate to good with maximum purity. All the synthesized compounds were characterized by various spectroscopic technique. All the synthesized compounds were tested for in-vitro antimicrobial biological evaluation in which the antibacterial activity of some compounds showed promising activity in comparison to standard drug streptomycin and ciprofloxacin, while the antifungal activity of all compounds showed higher to moderate activity against standard drug Nystatin. This study would be beneficial for further bio-evaluation.
Keywords: desulfitative, in-vitro antimicrobial activity, Nystatin.
Cite This Article:
Please cite this article in press Nagalatha et al, Synthesis And Characterization Of N-Methyl Indole Derivatives Via Desulfitative Displacement By Various Aniline Derivatives., Indo Am. J. P. Sci, 2021; 08(9).
Number of Downloads : 10
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