Volume : 09, Issue : 04, April – 2022

Title:

04.ANTI -ULCER ACTIVITY OF AQUEOUS EXTRACT OF ANNONA SQUAMOSA LEAVES ON RATS
‏‬

Authors :

Mosuru Praveen Kumar, Modalavalasa Sowmya, Palli Joshana, Pedada Nirosha, Swetha sri Sahu, Tadi Jyothi, Chandaka Madhu

Abstract :

The anti-ulcer activity of aqueous extract of Annona squamosa leaves was investigated on a indomethacin induced ulcer models in wistar rats. In model the common parameter determined was ulcer-index. aqueous extract of dosage 175, 350 mg/kg p.o produced significant inhibition of gastric lesions induced by indomethacin induced ulcers. The extract 175mg/kg & 350mg/kg showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicate that Annona squamosa leaves extract have potential anti ulcer activity. This results may further suggests that aqueous extract was found to posses antiulcerogenic as well as ulcer healing property,which might be anti secretory activity.
Keywords: anti-ulcer,annona squamosa, antisecretory ,indomethacin

Cite This Article:

Please cite this article in press Chandaka Madhu et al, Anti-Ulcer Activity Of Aqueous Extract Of Annona Squamosa Leaves On Rats., Indo Am. J. P. Sci, 2022; 09(4).,

Number of Downloads : 10

References:

1. Astin J. Why patients use alternative medicine? Results of a national survey. J Amer Med Associat. 1998; 279: 1548-1553.
2. Berenguer B Sanchez LM Qulilez A Lopez¬barreiro Galvez J Martin M.J; Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers. Journal of Ethnopharmacology,2005; 103: 104-200
3. BoreIli F Izzo AA., “The plant kingdom as a source of anti-ulcer remedies” Phytotheraphy research, 2000; 14: 581-591.
4. BVV Pardhasaradhi, Madhurima Reddy, A Mubarak Ali, A Leela Kumari and Ashok Khar, Differential cytotoxic effects of Annona squamosa seed extracts on human tumour cell lines: Role of reactive oxygen species and glutathione, J. Biosci, 2005,30(2), 237-244.
5. Chevallier A. The Encyclopedia of Medicinal Plants, Dorling Kindersly Ltd, London., 1996;10.
6. Dharmani P and Palit G. “Exploring Indian medicinal plants for anti-ulcer activity” Indian journal of pharmacology 2006; 38(2): 95-99.
7. Dinesh K. Yadava, Neetu Singhb, Rolee Sharmac, Mahendra Sahaid, Gautam Palitb, Rakesh Mauryaa, Anti-ulcer constituents of Annona squamosa Twigs, Fitoterapia, 2011, 82(4), 666-675.
8. Fugh-Berman A. Herb-drug interaction. Lancet. 2000; 355: 134-138.
9. Kannappan N S jaikumar manavalan R Kottai Muthu A: ” Anti-ulcer activity of methanolic extract of Jatropha curcas on Aspirin-induced gastric lesions in Wistar rats”. Pharmacologyonline. 2008; 1:279-293.
10. Kokate CK Purohit AP Gokhale SB Pharmacognosy.7th Edn, Nirali Prakashan, Pune, 1997:105-144.
11. Kulkarni SK. Hand book of experimental pharmacology, third edition, New Delhi, vallabh prakasham, 199,142-147.

12. Malairajan P Gopalakrishnan G Narasimhan S Veni KJK and Kavimani S “Antiulcer activity of crude alcoholic extract of Toona ciliata Roemer (heartwood)”Jouma/ of Ethnopharmacology. 2007; 110: 348-351.
13. Mohamed Saleem TS, Christina AJM, Chidambaranathan N, Ravi V, Gauthaman K, Hepatoprotective activity of Annona squamosa Linn. on experimental animal model, International Journal of Applied Research in Natural Products, 2008, 1(3), 1-7.
14. Mozafar Khazaei Hossein salehi, ” Protective effect of Falcaria Vulgaris on ethanol induced gastric ulcer in rats” Indian journal of Pharmacology and Therapeutics 2006;5: 43-46.
15. Narayan Das Prajapati, SS Purohit and Tarun Kumar. “A Hand Book of medicinal plants”
16. Neha Pandey, Dushyant Barve, Phytochemical and Pharmacological Review on Annona squamosa Linn, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2011, 2(4), 1404-1412
17. Parmar NS. “Effect of nalaxone and morphine on the experimentally induced Gastric ulers in rats” Indian Drugs 1991;29(7): 299-302
18. Rao,C.V., S.K. Ojha, K.Radhakrishnan, R. Govindarajan, S.Rastogi, S. Mehrotra and P. Pushpangadan, 2004. Antiulcer activity of Utleria salicifolia rhizome extract. J.Ethnopharmacol., 91: 243-249.
19. Vogel, W.H., B.A Scholkens, J. Sandow, G.Muller and W.F. Vogel, 2002. Drug Discovery and Evaluation, 2nd Edn., Springer, New York, ISBN- 13: 978-3540423966, pp: 670-725.