Volume : 09, Issue : 04, April – 2022
Title:
06.PHYTOCHEMICAL SCREENING AND ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF CISSAMPELOS PAREIRA LINN PENNEL LEAVES ON WISTAR ALBINO RATS
Authors :
Rokkala Prasanthi, Siraparapu Sridevi, Pontapalli Bharathi, Mindi Savithri, Guravana Sireesha, Chavali Aruna Kumari, Chandaka Madhu
Abstract :
Indomethacin induced ulcers in wistar rats was the main model of investigation of the anti-ulcer activity of the ethanolic extract of Cissampelos pareira Linn Pennel leaves in which ulcer index was used as the primary parameter. Inhibition of gastric lesions of the ethanolic extract of the leaves was observed at doses of 175mg/kg and 350 mg/kg when taken orally. At these doses, notable reduction in the gastric volume, free acidity and the ulcer index were observed when compared to the control group. From the results obtained, it can be noted that the ethanolic extract of Cissampelos pareira Linn Pennel leaves have anti-ulcer activity which can also be called as anti-secretory activity.
Key Words: Cissampelos pareira Linn Pennel, anti-ulcer activity, ulcer index, Indomethacin
Cite This Article:
Please cite this article in press Rokkala Prasanthi et al, Phytochemical Screening And Anti-Ulcer Activity Of Ethanolic Extract Of Cissampelos Pareira Linn Pennel Leaves On Wistar Albino Rats., Indo Am. J. P. Sci, 2022; 09(4).,
Number of Downloads : 10
References:
1. Astin J. Why patients use alternative medicine? Results of a national survey. J Amer Med Associat. 1998; 279: 1548-1553.
2. Berenguer B Sanchez LM Qulilez A Lopezbarreiro Galvez J Martin M.J; Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers. Journal of Ethnopharmacology,2005; 103: 104-200
3. BoreIli F Izzo AA., “The plant kingdom as a source of anti-ulcer remedies”Phytotheraphy research, 2000; 14: 581-591.
4. BVV Pardhasaradhi, Madhurima Reddy, A Mubarak Ali, A Leela Kumari and Ashok Khar, Differential cytotoxic effects of Cissampelos pareira Linn Pennelseed extracts on human tumour cell lines: Role of reactive oxygen species and glutathione, J. Biosci, 2005,30(2), 237-244.
5. Chevallier A. The Encyclopedia of Medicinal Plants, Dorling Kindersly Ltd, London., 1996;10.
6. Dharmani P and Palit G. “Exploring Indian medicinal plants for anti-ulcer activity”Indian journal of pharmacology 2006; 38(2): 95-99.
7. Dinesh K. Yadava, Neetu Singhb, RoleeSharmac, MahendraSahaid, Gautam Palitb, Rakesh Mauryaa, Anti-ulcer constituents of Cissampelos pareira Linn PennelTwigs, Fitoterapia, 2011, 82(4), 666-675.
8. Fugh-Berman A. Herb-drug interaction. Lancet. 2000; 355: 134-138.
9. Kannappan N S jaikumarmanavalan R KottaiMuthu A: ” Anti-ulcer activity of methanolic extract of Jatropha curcason Aspirin-induced gastric lesions in Wistar rats”. Pharmacologyonline. 2008; 1:279-293.
10. Kokate CK Purohit AP Gokhale SB Pharmacognosy.7thEdn, NiraliPrakashan, Pune, 1997:105-144.
11. Kulkarni SK. Hand book of experimental pharmacology, third edition, New Delhi, vallabhprakasham, 199,142-147.
12. Malairajan P Gopalakrishnan G Narasimhan S Veni KJK and Kavimani S “Antiulcer activity of crude alcoholic extract of Toona ciliata Roemer (heartwood)”Jouma/ of Ethnopharmacology. 2007; 110: 348-351.
13. Mohamed Saleem TS, Christina AJM, Chidambaranathan N, Ravi V, Gauthaman K, Hepatoprotective activity of Cissampelos pareira Linn PennelLinn. on experimental animal model, International Journal of Applied Research in Natural Products, 2008, 1(3), 1-7.
14. MozafarKhazaei Hossein salehi, ” Protective effect of Falcaria Vulgaris on ethanol induced gastric ulcer in rats”Indian journal of Pharmacology and Therapeutics 2006;5: 43-46.
15. Narayan Das Prajapati, SS Purohit and Tarun Kumar. “A Hand Book of medicinal plants”
16. Neha Pandey, Dushyant Barve, Phytochemical and Pharmacological Review on Cissampelos pareira Linn PennelLinn, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2011, 2(4), 1404-1412
17. Parmar NS. “Effect of nalaxone and morphine on the experimentally induced Gastric ulers in rats”Indian Drugs 1991;29(7): 299-302
18. Rao,C.V., S.K. Ojha, K.Radhakrishnan, R. Govindarajan, S.Rastogi, S. Mehrotra and P. Pushpangadan, 2004. Antiulcer activity of Utleriasalicifolia rhizome extract. J.Ethnopharmacol., 91: 243-249.
19. Vogel, W.H., B.A Scholkens, J. Sandow, G.Mullerand W.F. Vogel, 2002. Drug Discovery and Evaluation, 2nd Edn., Springer, New York, ISBN- 13: 978-3540423966, pp: 670-725.