Volume : 09, Issue : 04, April – 2022

Title:

18.DISINTEGRATING AGENTS THE BACKBONE OF MOUTH DISSOLVING TABLETS
‏‬

Authors :

Rathod. P.B* , Nimbalkar. A.V *, Jadhav. V.Y 1*, Juvatkar. P.V *, Indulkar. A.L , Kale. M.K , Gokhale. S.R , Titkare. J.R , Zambare.O.M , Vishe. R.R , Thakur. S.P ,
Shinde. T.M , Salvi. R.R

Abstract :

Mouth dissolving tablets (MDT) show the quick onset of action and are currently in demand because of several advantages like palatability and a pleasant mouthfeel. MDT can be consumed without water and shows effective action in a few minutes. MDT is advantageous particularly in all groups including pediatric, mentally ill, and geriatric patients who are unable to swallow conventional tablets and capsules. Disintegrants has a significant role in quick disintegration thereby enhancing its efficacy. In presence of super disintegrants, the tablet dissolves within 5-30 seconds range. Disintegrants are classified mainly into three categories natural, synthetic, and coprocessed. Various super disintegrants e.g. croscarmellose sodium, crospovidone, and sodium starch glycolate are added in MDT for faster dissolution. Various superdisintegrants are available in the market like ludiflash, fmelt, cellactose 80, microcelac 100 and avicel DG, etc
The review describes the various formulation aspects, techniques developed for MDTs, and super disintegrants used, along with evaluation tests, drugs, marketed formulation, and various excipients used for R&D.
Keywords: ODT, Mouth dissolving tablets, flash dose tablets, mouth disintegrating tablets, oral disintegrating tablets, super disintegrants

Cite This Article:

Please cite this article in press Piyush Rathod et al., Disintegrating Agents The Backbone Of Mouth Dissolving Tablets., Indo Am. J. P. Sci, 2022; 09(4).,

Number of Downloads : 10

References:

[1] Gagandeep Chawla* and Nitin JainSchool of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India. International Journal Of Pharmaceutical Sciences And Research ‘super disintegrants in the development of orally disintegrating tablets: a review’
[2] Dali SHUKLA, Subhashis CHAKRABORTY, Sanjay SINGH, Brahmeshwar MISHRA *Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India. ‘Mouth Dissolving Tablets I: An Overview of Formulation Technology’ (http://www.scipharm.at/)
[3] Gisel EG Oral motor skills following sensorimotor intervention the moderately eating impaired child with cerebral palsy. Dysphagia. 1994; 9: 180–192. http://dx.doi.org/10.1007/BF00341263
[4] M. Swamivelmanickam*, R. Manavalan and K. Valliappan Department of Pharmacy, Faculty of Engineering & Technology, Annamalai University, Annamalai Nagar, Tamilnadu, India ‘Mouth Dissolving Tablets: an overview’ Swamivelmanickam et al., IJPSR, 2010; Vol. 1 (12): 43-55 ISSN: 0975-8232
[5] Ashish Garg*, M.M. Gupta Jaipur College of Pharmacy, Jaipur (Rajasthan) India ‘Mouth Dissolving Tablets: A Review’Journal of Drug Delivery & Therapeutics; 2013, 3(2), 207-214, Available online at http://jddtonline.info
[6] European pharmacopoeia.
[7] Fix JA. ‘Advances in quick-dissolving tablets technology employing Wowtab’. Paper Presented at IIR Conference on Drug Delivery Systems. 1998 Oct.; Washington DC, USA
[8] Virely P, Yarwood R. Zydis ‘A Novel, Fast Dissolving Dosage Form’. Manuf Chem.. 1990; 61: 36–37.
[9] P. Ashish 1*, M.S. Harsoliya2, J.K.Pathan1, S. Shruti1 1. Swami Vivekanand College of Pharmacy, Indore 2. Research Scholar, JJT University, Rajasthan ‘A Review- Formulation of Mouth Dissolving tablet’http://www.urpjournals.com/journals.php?journalID=23
[10] Shihora, Hardikand Panda, Subhranshu, Journal of Pharmaceutical Science And Bioscientific Research, Vol. 2,148-152)
[11] Janet Roche Johnson, et al. (1991), ‘Effect of Formulation Solubility and Hygroscopicity on Disintegrant Efficiency in Tablets Prepared by Wet Granulation, in Terms of Dissolution’Journal of Pharmaceutical Sciences, 80 (5), 469-471.
[12]www.isppharmaceuticals.com/ISP-PH5284Polyplasdone.
[13] Michael, D Tousey (2002), ‘The Granulation Process 101 Basic Technologies for Tablet Making’ Pharmaceutical Technology Tableting and Granulation.8-13.
[14] Mohanachandran PS, Sindhumol PG and Kiran TS:‘Superdisintegrants: an overview’ Journal of Pharmaceutical Sciences Review and Research 2011; 6(1):105-109
[15] Kumaran AK, Sreekanth J and Palanisamy S,‘Formulation, development, and evaluation of Levodopa-Carbidopa orally disintegration tablets’Journal of Chemical and Pharmaceutical Research 2011; 3(3): 169-175.
[16] Shihora, Hardik and Panda, Subhranshu, Journal of Pharmaceutical Science And Bioscientific Research, Vol. 2,148-152.
[17] Lachmann, L,‘The Theory and Practice of Industrial Pharmacy’ Edition III, 317-322
[18] Gannu, Praveen Kumar and Raghu, Nirmala, ‘Fundamental Aspects of Superdisintegrants: A Concise Review’ Journal of Pharma Technology, 1-8.
[19] Patil, C, and Das, S (2011), ‘Effect of various super disintegrants on the drug release profile and disintegration time of Lamotrigine oral disintegrating tablets’African Journal of Pharmacy and Pharmacology, 5(1) 76-82.
[20] Raymond CR,‘Handbook of Pharmaceutical Excipients’APhA Publishers, Fifth Edition 2006.
[21] Uddhav S Bagul (2006). ‘Current status of tablet disintegrants: a review’ Retrieved March 5, 2011, from Pharmainfo.net.http://www.pharmainfo.net/reviews/current-status-tablet-disintegrantsa-review.
[22] Goel H, Rai P, Rana V and Tiwary AK,‘Orally disintegrating systems: innovations in formulation and technology’ Recent Patents on Drug Delivery & Formulation 2008; 2: 258-274.
[23] GK Bolhuis, AW Arends-Scholte, GJ Stuut and JA de Vries,‘Disintegration efficiency of sodium starch glycolates prepared from different native starches’European Journal of Pharmaceutics and Biopharmaceutics 1994; 40(5): 317 – 320.
[24] Paramita dey, Biswanath S A and Sabyasachi Maiti. Carboxymethyl,‘Ethers of locust bean gum a – review’Int. Journal of Pharmacy and Pharmaceutical Research, 3(2), 2011, 4-7.
[25] Douroumis D D, Gryczke A and Schminke S,‘Development and evaluation of cetirizine HCl taste-masked oral disintegrating tablets’AAPS Pharm. Sci. Tech, 12(1), 2011, 141-151.
[26] Smith G B, Huges D G, Kumar V,‘Temazepam in a fast dispensing dosage form as a pre-medication for children’Anaesthesia,40(4), 1985, 368-371.
[27] Bruna E, Leneveu A, Abouchaera M L, Delhotal B, Chauveau C, Rayot F, Fouvat B. ‘Acetaminophen flash tab formulation: fast disintegration and optimal absorption of the active ingredient’Proc Intl Symp Control Rel Bioact Mater, 25(4), 1998, 938-939.
[28] Sharma A, Agrwal S,‘Effect of oscimum basilicum on formulation and evaluation of rapidly disintegrated tablet of lamotrigine’IJPT, 4(3), 2012, 2169.
[29] Kumari S, Sharad V, Sharma P K, Yadav R K,‘Fast dissolving Drug delivery system: Review article’ Journal of Pharmacy Research, 3(6), 2010, 1444-1449.
[30] Bhowmik D, Chiranjib B, Krishnakanth, Pankaj, Chandira M R,‘Fast Dissolving Tablet: An Overview’Journal of Chemical and Pharmaceutical Research, 1(1), 2009, 163-177.
[31] Kumar R, Patil S, Patil MB, Patil SR and Paschapur MS,‘Isolation and evaluation of disintegrant properties of Fenugreek seed mucilage’International Journal of PharmTech Research 2009; 1(4): 982-996.
[32] Shah V and Patel R,‘Studies on mucilage from Hibiscus rosasinensis as oral disintegrant’International Journal of Applied Pharmaceutics 2010; 2(1): 18-21.
[33] Halakatti PK, Omer S, Gulgannavar RS and Patwari PK, ‘Formulation and evaluation of mouth disintegrating tablets of Famotidine by using Hibiscus rosasinensis mucilage and treated agar’ International Journal of Research in Ayurveda and Pharmacy 2010; 1(2): 497-505.
[34] Shirsand SB, Sarasija S, Para MS, Swamy PV and Kumar DN,‘Plantago ovata mucilage in the design of fast disintegrating tablets Indian Journal of Pharmaceutical Sciences 2009; IP: 210. 212. 120. 94.
[35]. Srinivas K, Prakash K, Kiran HR, Prasad P and Rao EB,‘Study of Ocimum basilicum and Plantago ovata as disintegrants in the formulation of dispersible tablets’ Indian Journal of Pharmaceutical Sciences 2003; 65(2): 180-183.
[36] Ghenge G, Pande SD, Ahmad A, Jejurkar L and Birari T,‘Development and characterization of the fast disintegrating tablet of Amlodipine besylate using mucilageof plantago ovata as a natural superdisintegrant’International Journal of PharmTech Research 2011; 3(2): 938-945.
[37] Malviya R, Srivastava P, Bansal M and Sharma PK,‘Preparation and evaluation of disintegrating properties of Cucurbita maxima pulp powder’International Journal of Pharmaceutical sciences 2010; 2(1): 395-399.
[38] Divekar VB, Kalaskar MG, Chougule PD, Redasani VK and Baheti, ‘Isolation and characterization of mucilage from Lepidium sativum Linn seeds’. International Journal of Pharmaceutical Research & Development 2010; 2(1): 1-5.
[39] Mehta KK, Patel HH, Patel ND, Vora CN and Patel NJ,‘Comparative evaluation of natural and synthetic super disintegrant for promoting Nimesulide dissolution for fast dissolving technology’International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2(3): 102-108.
[40] Nagar M and Yadav AV,‘Cinnarizine orodispersible tablets: a Chitosan-based fast mouth dissolving technology’International Journal of PharmTech Research 2009; 1(4): 1079-1091.
[41] Kumar R, Shirwaikar AA, Shirwaikar A, Prabhu SL, Mahalaxmi R, Rajendran K and Kumar DC,‘Studies on disintegrant properties of seed mucilage of Ocimum gratissimum’Indian Journal of Pharmaceutical Sciences 2007; 69(6): 753-758.
[42] Rao NGR, Kulkarni U, Rao KD and Suresh DK,‘Formulation and evaluation of fast dissolving tablets of Carbamazepine using natural super disintegrant Plantago ovata seed powder and mucilage’International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2(2): 70-74.
[43].Bhowmik D, Chiranjib B, Yadav J, Chandira RM and Kumar S,‘Emerging trends of disintegrants used in the formulation of solid dosage form’ Scholars Research Library Der Pharmacia Lettre 2010; 2 (1): 495-504.
[44] Shah B,‘Textbook of Pharmacognosy and Phytochemistry’Elsevier Health Sciences Publishers, First Edition 2009; 164-165.
[45] Setia A, Goyal N and Kansal S,‘Formulation and evaluation of Ciprofloxacin hydrochloride dispersible tablets using natural substances as disintegrates’Pelagia Research Library Der Pharmacia Sinica 2011; 2(1): 36-39.
[46] Alebiowu G and Itiola OA,‘The Influence of pregelatinized starch disintegrants on interacting variables that act on disintegrant properties’ Pharmaceutical Technology 2003; 28-33.
[47] Newman AW, Mueller RL, Vitez IM, and Kiesnowski CC,‘Starch and starch derivatives Encyclopedia of Pharmaceutical Technology, Informa Healthcare USA 2007.
[48] John C Carter. (2002-06). ‘The role of disintegrants in solid oral dosage form manufacturing Carter Pharmaceutical Consulting, Inc. Retrieved March 25, 2011 from http://www.carterpharma ceutical consulting.com/articles/The-role-of-disintergrants. html.
[49] Shaji J, Jain V and Lodha S, ‘Chitosan: a novel pharmaceutical excipient’ International Journal of Pharmaceutical and Applied Sciences 2010; 1(1): 11-28.
[50] Garnpimol CR, Parichat C, Sunibhond P and Piamsak M, ‘Chitin and Chitosan as disintegrants in Paracetamol tablets’ Drug Development and Industrial Pharmacy 1994; 20(13): 2109-2134.
[51] Chaudhary SA, Chaudhary AB and Mehta TA, ‘Excipients updates for orally disintegrating dosage forms’ International Journal of Research in Pharmaceutical Sciences 2010; 1(2): 103-207.
[52]John C Carter. (2002-06), ‘The role of disintegrants in solid oral dosage form manufacturing Carter Pharmaceutical Consulting’ Inc. Retrieved March 25, 2011 from http://www.carterpharma ceutical consulting.com/articles/The-role-of-isintergrants. html.
[53] Kumaran AK, Sreekanth J and Palanisamy S,‘Formulation, development, and evaluation of Levodopa-Carbidopa orally disintegration tablets’Journal of Chemical and Pharmaceutical Research 2011; 3(3): 169-175. April 28, 2011. <http://www.signetchem.com/Signet-The-Complete-Excipients-Company-Product-Ludiflash>. April 28, 2011. <http://www.pharma-ingredients.basf.com/Ludiflash/KeyFacts.aspx>.
[54] ‘Pharmaceuticals and excipients – F-melt’ May 25, 2011. <http://www.fujichemical.co.jp/english/medical/medicine/f-melt/index.html>.
[55] ‘Pharmaburst quick dissolve delivery system for tablets’June 10, 2011. <http://www.spipharma.com/downloads/Products/DDS/Pharmaburst_C1/Pharmaburst-TB.
[56] K. P. Raghava Kuchimanchi*1 and E. Suresh Kumar2,‘A Detailed Study On Disintegrating Agents And An Overview On Oral Disintegration Tablet’ International Journal of Research in Pharmaceutical and Nano Sciences. 5(3), 2016, 117 – 126.www.ijrpns.com
[57] Van Kamp HV, Bolhuis GK, de Boer AH, Lerk CF, Lie AHL,‘The role of water uptake on tablet disintegration’ Design of an improved method for penetration measurements. Pharm Acta Helv. 1986;61(1):22-29
[58] Augsburger LL, Brzeczko AW, Shah U, Hahm HA,‘Super disintegrants: characterization and function’ In: Swarbrick J, ed. Encyclopedia of Pharmaceutical Technology. 3rd ed. New York, NY: Informa Healthcare USA, Inc; 2007:3553-3567.
[59] Kissa E. Dispersions Characterization, Testing, and Measurement. New York, NY:Marcel Dekker, Inc; 1999.
[60] Konapure AS, Chaudhari PS, Oswal RJ, Kshirsagar SS, Antre RV, and Chorage TV: Mouth dissolving tablets-an innovative technology. International Journal of Applied Biology and Pharmaceutical Technology 2011; 2(1): 496-503.
[61] Pahwa R, Piplani M, Sharma PC, Kaushik D and Nanda S, ‘Orally disintegrating tablets – friendly to pediatrics and geriatrics’Archives of Applied Science Research 2010; 2(2): 35-48.
[62] Wilson CG, Washington N, Peach J, Murray GR, Kennerley J,‘The behavior of a fast-dissolving dosage form’ (Expidet) followed by g-scintigraphy. Int J Pharm. 1987; 40: 119–123.
[63] Nagendrakumar D, Raju SA, Shirsand SB, Para MS, ‘Design of fast dissolving granisetron HCl Tablets using novel co-processed super disintegrants.’ International journal of pharmaceutical sciences and review. 2010 March- April; 1(1):58-62.
[64] https://pharmaceutical.basf.com/global/en/drug-formulation/products/ludiflash.html
[65] ‘Pharmaceuticals and excipients’ F-melt. May 25, 2011. http://www.fujichemical.co.jp/english/medical/medicine/f-melt/index.html
[66] Joseph Zeleznik Manager, Technical & Regulatory Affairs MEGGLE USA, Inc. ‘Excipient Co‐processing Technologies Intelligent Combinations to Meet Current & Future Needs’
[67] Rajesh RoshanRai, Pavithra Chirra1, Venkataramudu Thanda, Department of Pharmaceutics, Gurunanak Institute of Pharmacy, Ibrahimpatnam, R.R District, 501506, A.P, India. Sree Vidyanikethan College of Pharmacy, Tirupati, 517102, A.P, India.‘Fast Dissolving Tablets: A Novel Approach To Drug Delivery – A Review’