Volume : 09, Issue : 04, April – 2022
Title:
31.FORMULATION AND IN-VITRO EVALUATION OF ULTRA-DEFORMABLE VESICULAR GEL OF ETODOLAC
Authors :
Bhushan R. Rane*, Vaibhav S. Dalvi, Ashish S. Jain, Sunil R. Bakliwal, Prashant L. Pingale
Abstract :
Transferosome is an ultra-deformable, highly flexible and stress-responsive complex system which consists of aqueous core surrounded composite lipid bilayer. Due to their resizing and self- optimized property, they are able to deliver low as well as high molecular weight into or through the skin. The main objective of this study is to prepare etodolac loaded transfersomes for the treatment of osteoarthritis. The dispersion of Etodolac loaded transfersomes was prepared by changing the ratio of surfactant and phospholipid by thin film hydration method. Prepared transferosme of Etodolac was optimized on the basis of various in-vitro evaluation characteristics such as zeta potential, TEM, etc. Optimized transferosome were further converted to Gel by using various concentrations of containing Carbopol 934. All gel formulations were evaluated for spreadability, extrudability, viscosity, pH, in vitro diffusion, stability study and found good results. From the % drug release kinetics study it was concluded that formulation follows zero order kinetics.
Keywords: Transfersomes, Gel, Etodolac, Zeta potential, TEM, Entrapment efficiency.
Cite This Article:
Please cite this article in press Bhushan R. Rane et al, Formulation And In-Vitro Evaluation Of Ultra-Deformable Vesicular Gel Of Etodolac., Indo Am. J. P. Sci, 2022; 09(04).,
Number of Downloads : 10
References:
1. Transdermal patch. https://en.wikipedia.org/wiki/Transdermal_patch (accessed on February 2, 2021).
2. Bhasin B.; Londhe V. Y. An overview of transfersomal drug delivery. International J of Pharmaceutical Sciences and Research. 2018. Vol. 9(6):2175-2184.
3. Chaurasiya P.; Ganju E.; Upmanyu N.; ray S. K.; and Jain P. Transfersome: a novel technique for transdermal drug delivery. Journal of Drug Delivery and Therapeutics. 2019. 9(1):279-285.
4. Modi C. D.; Bharadia P. D.; Transfersomes: A New Dominats for Transdermal Drug Delivery. American Journal of Pharmatech Research. 2012. 2(3) 71-91.
5. Rai K.; Gupta Y.; Jain A.; Jain S.; Transfersomes: self-optimizing carriers for bioactive. PDA J of Pharm sci Technol. 2008, 62(5)362-79.
6. Bakliwal S.; Dr. Rane B.; Dr. Jain A.; A Glimpse of novel drug delivery system 1st ed., nirali prakashan. 2017. 7.1-7.4.
7. Kumar A.; nayak A.; Ghatuary S.; Dasgupta S.; Jain A. Transfersomes: a recent approach for transdermal drug delivery. Journal of Drug Delivery and Therapeutics. 2018. 8(5-s):100-104.
8. Ahmed F., Dr. Shahidulla., Ahmed J., Mubin H. Transfersomes ultradeformable delivery carriers. International Journal for Research Trend and Innovations. 2020. Volume 5: 91-94.
9. Chaurasiya P., Ganju E., Ray SK., Jain P, Transfersomes: a novel technique for transdermal drug delivery, Journal of Drug Delivery and Therapeutics. 2019. 9(1):279-285.
10. Thakur N.; Thakur P.; Jain V. development and evaluation clindamycin phosphate transfersomal gel. Journal of Drug Delivery and Therapeutics. 2018. 8(5):168-177.
11. Jaiswal. P.; Kesharwani S.; Kesharwani R.; Patel D. Ethosome: A New Technology Used as Topical & Transdermal Delivery System. Journal of Drug Delivery and Therapeutics. 2016. 6(3):7- 17.
12. Ashara K.; Paun J.; Soniwala M.; Chavda J. Vesicular drug delivery system: A novel approach. Mintage journal of pharmaceutical & medical science. 2014. Vol-3:1-15.
13. Eldhose M.; Mathew F.; Mathew N. Transfersomes A Review. International J pharmacy and pharmaceutical research. 2016, volume 6 (4): 436-452.
14. Rane S.; Rane B.; Jain A. Formulation Development and Evaluation of Niosomal Gel Loaded with Tinidazole Niosome. World journal of Pharmaceutical Research. July 2018, volume- 07: 847-837.
15. Gouda R., Baishya H., Quing Z. Aoolication of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets. Journal of Developing Drugs. 2017, Volume 6: 1-8.