Volume : 09, Issue : 04, April – 2022

Title:

37.ROLE OF TOPICAL FLAVONOIDS AS ANTIOXIDANTS TO PRESERVE HEALTHY SKIN – A REVIEW
‏‬

Authors :

Sonam Sasi*, Dr. Subhash Chandran M P, Dr. Prashob G R, Shilpa Suresh

Abstract :

As a result of the negative effect of some of the horny extract’s associated proteins, the skin is continuously exposed to numerous environmental factors, particularly pollution as well as ultraviolet radiation (UV). As a result, the horny isolate can be adversely affected by the toxic influence of many of its associated proteins. The immediate absorption of UV light through the use of epithelial chromophores, the creation of excited states as well as the subsequent chemical changes, or even photosensitization processes, wherein UV light is absorbed by excited photosensitizer and their responses encourage the production of reactive oxygen species, are all processes that are involved in the environmental pollutants advanced by UV light. Polluting chemicals’ actions are not completely understood, but evidence suggests that one of the key processes involved is oxidative stress caused by lipid peroxidation, which has the potential to cause harm to sebum content, stratum corneum integrity, and skin ageing. Numerous studies have indicated the effectiveness of natural antioxidants, with a focus on natural substances, in promoting the preservation of the skin’s physiological equilibrium.
Key words: Antioxidants, cosmetics, epidermis, flavonoids, quercetin, skin.

Cite This Article:

Please cite this article in press Sonam Sasi et al, Role Of Topical Flavonoids As Antioxidants To Preserve Healthy Skin – A Review., Indo Am. J. P. Sci, 2022; 09(04).,

Number of Downloads : 10

References:

1. Contassot E, Beer HD, French LE. Interleukin-1, inflammasomes, autoinflammation and the skin. Swiss Med Wkly 2012;142:w13590.
2. Song S, Lee K, Lee YM, Lee JH, Lee SI, Yu SD, et al. Acute health effects of urban fine and ultrafine particles on children with atopic dermatitis. Environ Res 2011;111:394-9.
3. Ahn K. The role of air pollutants in atopic dermatitis. J Allergy Clin Immunol 2014;134:993-9.
4. Kular JK, Basu S, Sharma RI. The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering. J Tissue Eng 2014;5:2041731414557112.
5. Kamble P, Sadarani B, Majumdar A, Bhullar S. Nanofiber based drug delivery systems for skin: A promising therapeutic approach. J Drug Deliv Sci Technol 2017;41:124-33.
6. Velasco MV, Sauce R, Oliveira C, Pinto CA, Martinez RM, Baah S, et al. Active ingredients, mechanisms of action and efficacy tests of antipollution cosmetic and personalcare products. Braz J Pharm Sci 2018;54:54.
7. Marrot L. Pollution and sun exposure: A deleterious synergy. Mechanisms and opportunities for skin protection. Curr Med Chem 2019;25:5469-86.
8. Balogh TS, Velasco MV, Pedriali C, Kaneko TM, Baby AR. Proteção à radiação ultravioleta: Recursos disponíveis na atualidade em fotoproteção. An Bras Dermatol 2011;86:732-42.
9. American Cancer Society (ACS). Learn About Cancer. What Causes Cancer. Sun and UV Exposure. Skin Cancer Prevention and Early Detection. What Is Ultraviolet (UV) Radiation? 2013. Available from: https://www.cdc. gov/cancer/skin/basic_info/what-is-skin-cancer.htm. [Last accessed on 2020 Jan 02].
10. Soeur J, Belaïdi JP, Chollet C, Denat L, Dimitrov A, Jones C, et al. Photo-pollution stress in skin: Traces of pollutants (PAH and particulate matter) impairredox homeostasis in keratinocytes exposed to UVA1. J Dermatol Sci 2017;86:162-9.
11. Maverakis E, Miyamura Y, Bowen MP, Correa G, Ono Y, Goodarzi H. Light, including ultraviolet. J Autoimmun 2010;34:J247-57.
12. Sharma P, Tailang M. Design, optimization, and evaluation of hydrogel of primaquine loaded nanoemulsion for malaria therapy. Futur J Pharm Sci 2020;6:1.
13. Sharma P, Tailang M. In-vivo study of orodispersible tablet of primaquine. Int J Pharm Sci Res 2018;9:3506-10.
14. De Lima Cherubim DJ, Buzanello Martins CV, Oliveira FL, da Silva de Lucca RA. Polyphenols as natural antioxidants in cosmetics applications. J Cosmet Dermatol 2020;19:33-7.
15. Silva S, Ferreira M, Oliveira AS, Magalhães C, Sousa ME, Pinto M, et al. Evolution of the use of antioxidants in anti-ageing cosmetics. Int J Cosmet Sci 2019;41:378-86.
16. Babbush KM, Babbush RA, Khachemoune A. The therapeutic use of antioxidants for melasma. J Drugs Dermatol 2020;19:788-92.
17. Augustyniak A, Bartosz G, Cipak A, Duburs G, Horáková L, Luczaj W, et al. Natural and synthetic antioxidants: An updated overview. Free Radic Res 2010;44:1216-62.
18. Kim JJ, Kim KS, Yu BJ. Optimization of antioxidant and skin-whitening compounds extraction condition from Tenebrio molitor Larvae (Mealworm). Molecules 2018;23:E2340.
19. He H, Li A, Li S, Tang J, Li L, Xiong L. Natural components in sunscreens: Topical formulations with sun protection factor (SPF). Biomed Pharmacother 2021;134:111161.
20. Sharma P. Modification of human behavior due to coronavirus outbreak: A brief study
21. Farage MA, Miller KW, Elsner P, Maibach HI. Intrinsic and extrinsic factors in skin ageing: A review. Int J Cosmet Sci 2008;30:87-95. 22. Rees JL. The genetics of sun sensitivity in humans. Am J Hum Genet 2004;75:739-51.
22. Rees JL. The genetics of sun sensitivity in humans. Am J Hum Genet 2004;75:739-51.
23. Krutmann J, Schikowski T, Morita A, Berneburg M. Environmentally-induced (extrinsic) skin aging: Exposomal factors and underlying mechanisms. J Investig Dermatol 2021;141:1096-103.
24. Flament F, Bazin R, Qiu H, Ye C, Laquieze S, Rubert V, et al. Solar exposure(s) and facial clinical signs of aging in Chinese women: Impacts upon age perception. Clin Cosmet Investig Dermatol 2015;8:75-84.
25. Morais ML, Silva AC, Araújo CR, Esteves EA, Dessimoni-Pinto NA. Determinação do potencial antioxidante in vitro de frutos do cerrado brasileiro. Rev Bras Frutic 2013;35:355-60.
26. Bose B, Choudhury H, Tandon P, Kumaria S. Studies on secondary metabolite profiling, anti-inflammatory potential, in-vitro photoprotective and skin-aging related enzyme inhibitory activities of Malaxis acuminata, a threatened orchid of nutraceutical importance. J Photochem Photobiol B Biol 2017;173:686-95.
27. Leopoldini M, Russo N, Toscano M. The molecular basis of working mechanism of natural polyphenolic antioxidants. Food Chem 2011;125:288-306. 28. Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci 2017;19:70.
29. Rajaram S, Jones J, Lee GJ. Plant-based dietary patterns, plant foods, and age-related cognitive decline. Adv Nutr 2019;10:S422-36.
30. Cavinato M, Waltenberger B, Baraldo G, Grade CVC, Stuppner H, Jansen-Dürr P. Plant extracts and natural compounds used against UVB-induced photoaging. Biogerontology 2017;18:499-516