Volume : 09, Issue : 04, April – 2022
Title:
38.LEARNING AND MEMORY ACTIVITY OF CUCURBITA PEPO AGAINST DIAZEPAM INDUCED AMNESIA AND ETHANOL INDUCED COGNITIVE IMPAIRMENT IN RODENTS BY USING MORRIS WATER MAZE (MWM)
Authors :
Kakunuri Lakshmi *, Adapa Sowmya, Bathina Vara Lakshmi, Tejavathu Vijaya Lakshmi, Bhukya Ratna Madhuri, Peddarapu Sandhyarani, Sandipamu Savitri, Somavarapu Pravallika, Guda Swathi
Abstract :
The Cucurbitaceae family, also referred as cucurbits form a very large group with approximately 130 genera and 800 species and can be cultivated in warmer region of worldwide and make popular food crop plants some of these species include squashes, pumpkins, melons and gourds. Pumpkin belongs to the genus Cucurbita and the family Cucurbitaceae. The objective of this study was to identify the potential of Cucurbita pepo as protective and therapeutic agent against Alzheimer’s disease. The learning and memory enhancing activity of Cucurbita pepo seed extract were investigated in rats by using the ethanol induced cognitive impairment and diazepam induced amnesia and its effects on learning and memory were examined by using Morris water maze (MWM) test. For Morris water maze test all groups showed significantly (P value is < 0.01 & < 0.05) decreases transfer latency time at all periods as compared to ethanol and diazepam inducing group Therefore seed extracts of Cucurbita pepo exhibited significantly learning and memory activity in Alzheimer’s disease.
KEY WORDS: Cucurbita pepo, learning and memory activity, Morris water maze and Alzheimer’s disease.
Cite This Article:
Please cite this article in press Kakunuri Lakshmi et al, Learning And Memory Activity Of Cucurbita Pepo Against Diazepam Induced Amnesia And Ethanol Induced Cognitive Impairment In Rodents By Using Morris Water Maze (MWM)., Indo Am. J. P. Sci, 2022; 09(04).,
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